Expected ameliorative effect of fennel oil on the teratogenicity of topiramate treated albino rats / (Record no. 81457)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03344cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032755.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210703s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.25.M.Sc.2021.Na.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nadeen Diaa Eldin Abdelqadir Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Expected ameliorative effect of fennel oil on the teratogenicity of topiramate treated albino rats / |
| Statement of responsibility, etc. | Nadeen Diaa Eldin Abdelqadir Mohamed ; Supervised Taha Mohamed Eldebss , Abdelwahab Elghareeb , Heba Ali Abdelrahman |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تاثير التحسين المتوقع لزيت الشمر على تشوهات اجنه الجرذان البيضاء المعالجه بالتوبيراميت |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nadeen Diaa Eldin Abdelqadir Mohamed , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 138 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The topiramate which belongs to a sulfamate-substituted monosaccharide compound is a drug used mainly in the treatment of epilepsy in both adults and children. Recent studies suggest that administration of topiramate to pregnant women increases the risk of birth defect in the offspring and possible also other adverse effect in the exposed infant. The present work studied the ameliorative effect of fennel oil against teratogenic effect which induced by the topiramate in albino rats. The animals were divided into 4 groups: group 1 (control), group 2: the pregnant rat orally given fennel oil (1 ml/kg body weight), group 3: the pregnant rat orally-administered with human equivalent dose (100 mg/kg) of topiramate and group 4: the pregnant rat orally-administered with topiramate followed by fennel oil from 5th day of gestation to 19th day of gestation. The pregnant rats were sacrificed under anesthesia at 20th day of gestation.The uteri horns were isolated and the numbers of resorbed sites were determined. In addition, the morphological examination and skeletal staining of fetuses and the histological studies on placenta, fetal liver, fetal kidney and fetal brain have been done. The Result showed decrease in both corrected body weight and placenta weight of pregnant mother and high incidence of resorption. Many hematomas in different part of body and other malformations represented in deformed fore limb were recorded in group treated with topiramate.The skeletal malformation summarized as less degree ossification, complete unossified bones, wavy ribs, curved ribs and costal separation in group treated with topiramate.The histopathological change summarized in degeneration of giant cells, pyknotic spongiotrophoblast and necrotic areas in histology of placenta, also shrinkage of glomeruli, pyknotic nuclei and disintegration of cells lining tubules were detected in histology of kidney |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pregnant rats |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Teratogenecis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Topiramate |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelwahab Elghareeb , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Ali Abdelrahman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Taha Mohamed Eldebss , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.25.M.Sc.2021.Na.E | 01010110083772000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.25.M.Sc.2021.Na.E | 01020110083772000 | 22.09.2023 | CD - Rom | 83772.CD |