Assessment of PD-1 and PD-L1 levels in vitiligo patients : (Record no. 81486)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03098cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032755.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210706s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.Ph.D.2021.Ah.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Hesham Ezz Eldin Mohamed Mourad |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of PD-1 and PD-L1 levels in vitiligo patients : |
| Remainder of title | Case control study / |
| Statement of responsibility, etc. | Ahmed Hesham Ezz Eldin Mohamed Mourad ; Supervised Hanan Rabea Nada , Ghada Mohamad Elhanafi , Mohamed Abdelhady |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | في مرضى البهاق PD-L1 1-ولجين موت الخلية المبرمج PD-1 1- تقييم مستوى عامل موت الخلية المبرمج : |
| Remainder of title | دراسة الحالات والشواهد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Hesham Ezz Eldin Mohamed Mourad , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 109 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Programmed cell death 1 (PD-1) is an immune checkpoint cell surface protein with two ligands, PD-L1 and PD-L2. PD-1/PD-L1 interactions are essential for peripheral T cell tolerance and protecting tissues from autoimmune attack. PD- 1/PD-L1 checkpoint is implicated in multiple autoimmune diseases, and recently were suggested to have a role in vitiligo development due to the high incidence of vitiligo like lesions as an adverse effect of PD-1/PD-L1 blockade. Aim of work: To assess both PD-1 and PD-L1 levels in vitiligo patients{u2019} marginal and nonlesional biopsies in comparison with normal controls, and to correlate them with disease parameters. Methods: 30 vitiliginous patients and 30 age and sex matched controls were included. Full history and clinical examination were done and tissue levels of PD1 were measured by ELISA from lesional and nonlesional biopsies. Results: Levels of tissue PD-1 in marginal biopsies were significantly higher than in nonlesional biopsies (p<{u2009}.001) and significantly higher than control PD-l level (p<{u2009}.001). Nonlesional PD-1 level was also significantly higher than control PD-l level (p<{u2009}.001). A statistically significant positive correlation was found between marginal and nonlesional PD-1 levels; (rho=0.792, p<{u2009}.001). Levels of tissue PD-L1 in marginal biopsies were significantly lower than in nonlesional skin (p<0.001) and significantly lower than in controls (P<0.001). Nonlesional PD-L1 level was also significantly lower than control PD-Ll level (p<{u2009}.001). Conclusion: PD-1/PD-L1 may be involved in the pathogenesis of vitiligo |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Programmed cell death 1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tolerance |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vitiligo |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghada Mohamad Elhanafi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Rabea Nada , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Abdelhady , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.Ph.D.2021.Ah.A | 01010110083787000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.Ph.D.2021.Ah.A | 01020110083787000 | 22.09.2023 | CD - Rom | 83787.CD |