Role of ESR1 and FTO genetic variants on weight loss and glycemic control in obese patients undergoing bariatric surgery / (Record no. 81533)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03035cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032757.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210801s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2021.Su.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Susan Sameh Ahmed Fathy Elzayat |
| 245 10 - TITLE STATEMENT | |
| Title | Role of ESR1 and FTO genetic variants on weight loss and glycemic control in obese patients undergoing bariatric surgery / |
| Statement of responsibility, etc. | Susan Sameh Ahmed Fathy Elzayat ; Supervised Marwa Mohamed Sheta , Mohamed Diaa Eldin Sarhan , Tarek Abdelazim Ramzy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى فقدان الوزن و مراقبه نسبه السكر فى الدم فى المرضى الذين يعانون من السمنة المفرطة وسيخضعون لجراحه لعلاج البدانة FTO و ESR1 دور المتغيرات الوراثية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Susan Sameh Ahmed Fathy Elzayat , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 127 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Significant variability in weight loss and glycemic control has been observed in obese patients undergoing bariatric surgery. Genetic factors may play a role in the different outcomes. Objectives: The aim of this study is to detect the effect of genetic variants within the FTO gene (rs9939609) and ESR1 gene (rs712221) on weight loss and glycemic control in obese patients 6 months after laparoscopic sleeve gastrectomy. Patients and Methods: Ninety obese patients with BMI {u2265} 35 kg/m2undergoing laparoscopic sleeve gastrectomywere recruited and followed up after 6 months. All were subjected to history taking, clinical examination, routine laboratory investigations and genotyping for FTO gene (rs9939609) and ESR1 gene (rs712221) usingReal Time-PCR (TaqMan probes). Results: FTO (rs9939609) risk genotype AA is found to be associated with more obesity before operation (P-value 0.005) and lead to successful surgery and weight loss (P-value 0.023, OR 0.080, 95%CI 0.009-0.702). Patients with risk allele A had more weight loss and BMI loss after operation compared to patients with non-risk allele T (P-value <0.001). ESR1 (rs712221) risk genotype TT is found to be associated with more weight loss 6 months after surgery when compared to non-risk genotypes TA and AA (P-value 0.001). Patients with risk allele T had more weight loss, BMI loss and HbA1c loss after operation compared to patients with non-risk allele A (P-value <0.001) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ESR1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | FTO |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | laparoscopic sleeve gastrectomy |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Mohamed Sheta , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Diaa Eldin Sarhan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek Abdelazim Ramzy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2021.Su.R | 01010110083806000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2021.Su.R | 01020110083806000 | 22.09.2023 | CD - Rom | 83806.CD |