Diagnosis of invasive aspergillosis by biomedical spectroscopy / (Record no. 81756)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02991cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032803.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210816s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.06.M.Sc.2021.Om.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Omar Mohamed Anwar Mahmoud Elkadi |
| 245 10 - TITLE STATEMENT | |
| Title | Diagnosis of invasive aspergillosis by biomedical spectroscopy / |
| Statement of responsibility, etc. | Omar Mohamed Anwar Mahmoud Elkadi ; Supervised Mohammed Abdelhaleem Ramadan , Mervat Gabar Elanany |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشخيص داء الرشاشيات باستخدام المطيافية الطبية الحيوية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Omar Mohamed Anwar Mahmoud Elkadi , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 94 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Invasive aspergillosis is a challenging infection that requires convenient, efficient, and cost-effective diagnostics. This study addresses the potential of infrared spectroscopy to satisfy this clinical need with the aid of machine learning by creating and assessing models that identify the presence of Aspergillus species in human blood plasma. For training of the machine learning models, clinical isolates of three Aspergillus species (A. fumigatus, A. flavus, and A. niger) in addition to Penicillium chrysogenum have been collected and identified by their macroscopic and microscopic morphology, and confirmed by MALDI-TOF MS. Two models, based on Partial Least Squares-Discriminant Analysis (PLS-DA), have been trained by a set of infrared spectral data of 9 Aspergillus-spiked (three of each collected Aspergillus species) and 7 Aspergillus-free plasma samples (including 2 samples spiked with P. chrysogenum), and a set of 200 spectral data simulated by oversampling these 16 samples. Two further models have also been trained by the same sets but with auto-scaling performed prior to PLS-DA.These models were assessed using 45 mock samples, simulating the challenging samples of patients at risk of invasive aspergillosis, including the presence of other common bloodstream pathogens (5 tested) and drugs (9 tested) as potential confounders.The pathogen tested as potential confounders are clinical isolates of Candida albicans, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus epidermidis that have been collected and identified by conventional phenotypic method including culture morphology, microscopic examination, and biochemical reactions |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aspergillosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Infrared spectroscopy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Machine learning |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mervat Gabar Elanany , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Abdelhaleem Ramadan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.06.M.Sc.2021.Om.D | 01010110083933000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.06.M.Sc.2021.Om.D | 01020110083933000 | 22.09.2023 | CD - Rom | 83933.CD |