Evaluating the use of metallic nanoparticles as a modality for enhancing the photodynamic action of hypericin on cancer cells : (Record no. 81785)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03085cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032804.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210822s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.24.05.Ph.D.2021.Sh.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shimaa Abdelhamid Abdelkhalek |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluating the use of metallic nanoparticles as a modality for enhancing the photodynamic action of hypericin on cancer cells : |
| Remainder of title | In vitro study / |
| Statement of responsibility, etc. | Shimaa Abdelhamid Abdelkhalek ; Supervised Abdallah F. Zedan , Kawser Kassab , Taher Salaheldin |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم استخدام جسيمات النانو المعدنيه كوسيله لتحسين الحث الضوئى الديناميكى للهيبرسين على الخلايا السرطانيه : |
| Remainder of title | دراسه معمليه |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shimaa Abdelhamid Abdelkhalek , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 117 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Application in Enviromental Metrology, Photochemistry and Photobiology and Agriculture |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hypericin has gained a great attention as a powerful photosensitizing and fluorescent agent for photodynamic therapy (PDT) and fluorescence diagnosis (FD) of cancer. However, the hydrophobic nature of hypericin and the tendency to form aggregates in aqueous environments constitute the most common obstruction restricting its biological applications.The reported studies about the photophysical properties of hypericin such as fluorescence, extinction coefficient, and quantum yield concluded that hypericin remains photoactive only while it is existing in the monomeric state. Hence, the aqueous formulae of hypericin are not biologically active unless they are chemically modified to remain in the monomeric state. In this thesis, different formulae of hypericin in aqueous media were prepared to improve the water solubility of hypericin for the different biological applications. Hypericin was first encapsulated with polyvinylpyrrolidone (hypericin@PVP) and the absorption and emission characteristics of hypericin@PVP in water were studied at room temperature. Also, the photostability of the prepared hypericin@PVP was studied under visible light irradiation. Upon encapsulation with PVP, hypericin possessed an improved solubility and stability in water as revealed by the relatively enhanced absorption and emission in water.The effect of the molecular weight of the PVP was assessed by adopting PVP with two different molecular weight, namely 10 and 360 KD. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hypericin on cancer cells |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Metallic nanoparticles |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Photodynamic action |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdallah F. Zedan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kawser Kassab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Taher Salah Eldin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.24.05.Ph.D.2021.Sh.E | 01010110083959000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.24.05.Ph.D.2021.Sh.E | 01020110083959000 | 22.09.2023 | CD - Rom | 83959.CD |