MARC details
| 000 -LEADER |
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| fixed length control field |
03208cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210828s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.08.09.M.Sc.2021.Ma.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Marina Ramsis Fouad Youssef |
| 245 10 - TITLE STATEMENT |
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| Title |
Effect of vildagliptin in treatment of experimentally induced {u2013}ulcerative colitis in rats / |
| Statement of responsibility, etc. |
Marina Ramsis Fouad Youssef ; Supervised Hala Ahmed Fahmy Zaki , Ayman Elsayed Mohamed Elsahar , Rania Mohamed Kamel Hassan Mohamed Salama |
| 246 15 - VARYING FORM OF TITLE |
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| Title proper/short title |
دراسة تأثير ال{u٠٦ء٤}لداجلبتن فى نموذج تجريبى لالتهاب القولون التقرحى فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Marina Ramsis Fouad Youssef , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
136 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Ulcerative colitis (UC) is a chronic bowel disease depicted by the involvement of pro-inflammatory cytokines.The release of these cytokines is regulated by phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/nuclear factor-kappa B (NFmB) and cAMP response element-binding protein (CREB) signaling pathways as well as over expression of microRNA 146a (miR-146a) and long non-coding RNA interferon gamma antisense 1 (lncRNA IFNG-AS1). Vildagliptin (Vilda), a dipeptidyl peptidase IV (DPP-IV) inhibitor, has an anti-inflammatory, antioxidant and anti-apoptotic effects which were established in various models. However, its possible protective effect in UC has not been clarified. Hence, the current study aimed to explore the possible prophylactic effect of different doses of Vilda against acetic acid (AA)-induced UC in rats. Forty-eight adult male Wistar rats were divided into six groups: control, Vilda (10 mg/kg/day; p.o.), AA, AA+Vilda (5 mg/kg/day; p.o.), AA+Vilda (10 mg/kg/day; p.o.) and AA+sulfasalazine (Sulfa) (100 mg/kg/day; p.o.).Low- and high-dose Vilda showed a significant improvement in the disease activity index (DAI) and macroscopic assessment markers. Vilda has markedly modulated the expression of lncRNA IFNG-AS1 and miR-146a, as well as PI3K/Akt/NFmB, CREB and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways, which was reflected in alleviated oxidative stress, inflammation and apoptosis. Such outcomes were more prominent with the high-dose Vilda against low-dose Vilda and Sulfa. Moreover, the histological examination showed almost intact histological features in Vilda-treated groups when compared to AA group. In conclusion, Vilda can be regarded as a new promising therapeutic alternative against UC with higher benefit shown with high-dose Vilda |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
PI3K/Akt/CREB |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Ulcerative colitis |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Vildagliptin |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ayman Elsayed Mohamed Elsahar , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hala Ahmed Fahmy Zaki , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rania Mohamed Kamel Hassan Mohamed Salama , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
