MARC details
| 000 -LEADER |
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| fixed length control field |
03463cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210828s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.08.01.Ph.D.2021.Yo.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Yomna Rashad Ahmed Abdelmohsen |
| 245 10 - TITLE STATEMENT |
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| Title |
Effect of adenosine A2A receptor antagonist, niacin and curcumin as neuroprotective agents against Parkinson{u2019}s disease induced by rotenone in mice / |
| Statement of responsibility, etc. |
Yomna Rashad Ahmed Abdelmohsen ; Supervised Tarek M. Kamal Motawi , Nermin Abdelhamid Sadik , Manal Abdelaziz Hamed |
| 246 15 - VARYING FORM OF TITLE |
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| Title proper/short title |
و النياسين و الكركمين كعوامل واقية للأعصاب ضد مرض شلل الرعاش المحدث بالروتينون فى الفئران A2A تأثير مضاد مستقبل الادينوزين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Yomna Rashad Ahmed Abdelmohsen , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
139 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Parkinson{u2019}s disease (PD) is the second common age-related neurodegenerative disease. It is characterized by control loss of voluntary movements control, resting tremor, postural instability, bradykinesia, and rigidity.The aim of the present work is to evaluate curcumin, niacin, dopaminergic and non-dopaminergic drugs in mice model of Parkinson{u2019}s disease through behavioral, biochemical, genetic and histopathological observations. Mice treated with rotenone rerecorded significant increase in adenosine A2A receptor (A2AR) gene expression, Ü synuclein, acetylcholinesterase (AchE), malondialdehyde (MDA), angiotensin-II (Ang-II), c-reactive protein (CRP), interleukin-6 (IL-6), caspase-3 and DNA fragmentation levels as compared with the control group. While, significant decrease in dopamine (DA), nor adrenaline (NA), serotonin (5-HT), superoxide dismutase (SOD), reduced glutathione (GSH), adenosine triphosphate (ATP), succinate and lactate dehydrogenases (SDH &LDH) levels were detected.Treatment with curcumin, niacin, adenosine A2AR antagonist; ZM241385 and their combination enhanced the animals{u2019} behavior and restored all the selected parameters with variable degrees of improvement. The brain histopathological features of hippocampal and substantia nigra regions confirmed our results. In conclusion, the combination of curcumin, niacin and ZM241385 recorded the most potent treatment effect in Parkinsonism mice followed by ZM241385, as a single treatment. ZM241385 succeeded to antagonize adenosine A2A receptor by diminishing its gene expression and ameliorating all biochemical parameters under investigation.The newly investigated agent; ZM241385 has almost the same pattern of improvement as the classical drug; Sinemet®. This could shed the light to the need of detailed studies on ZM241385 for its possible role as a promising treatment against PD. Additionally, food supplements such as curcumin and niacin were effective in Parkinson{u2019}s disease eradication |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Curcumin |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Niacin |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Rotenone |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Manal Abdelaziz Hamed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Nermin Abdelhamid Sadik , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Tarek M. Kamal Motaw , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
