MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02812cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
210828s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.01.M.Sc.2021.Ma.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mai Zakaria Mohyeldeen Mahmoud |
| 245 14 - TITLE STATEMENT |
|---|
| Title |
The possible association of some P53-related long non coding RN As and hepatitis C-induced hepatocellular carcinoma in Egyptian patients / |
| Statement of responsibility, etc. |
Mai Zakaria Mohyeldeen Mahmoud ; Supervised Safinaz Samy Ibrahim , Olfat Gamil Shaker , Hebatullah Samy Mohammed Helmy |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
وسرطان الكبد الناجم عن الالتهاب الكبدي الوبائى (ج) فى المرضى المصريين P53 العلاقة المحتملة بين بعض أحماض الريبونيوكليك الطويلة الغير منتجة للبروتين المرتبطة بالبروتين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mai Zakaria Mohyeldeen Mahmoud , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
63 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: The present study investigated the serum detectability and the diagnostic implications of long noncoding RNAs; nuclear enriched abundant transcript 1 (NEAT1) and taurine upregulatedgene1(TUG1) in viral hepatitis C(HCV)and HCV-induced hepatocellular carcinoma (HCC). Methods: The study included twenty healthy controls, forty non-malignant HCV patients and forty HCV-associated HCC patients.The study assessed liver function tests, the antioxidant status, serumal phafeto protein, p53, NEAT1 and TUG1. Results: Diminished serum expression of NEAT1 and TUG1 was observed in HCV and HCV-induced HCC and was closely associated with deregulated liver function and elevated AFP levels.A model of NEAT1, TUG1 and AFP accurately differentiated between HCC patients and healthy subjects with sensitivity higher than that of AFP alone. Additionally, the diagnostic performance of a model of TUG1, p53 and AFP was superior to that of each marker alone for predicting HCC in HCV patients. Conclusion: Significant alterations in the serum expression of NEAT1 and TUG1 in HCV and HCV-associated HCC patients were recorded. We propose NEAT1 and TUG1 as non-invasive, cost-effective and complementary biomarkers that improve the diagnostic characteristics of AFP |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Hepatocellular carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Long non-coding RNA |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
NEAT1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hebatullah Samy Mohammed Helmy , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Olfat Gamil Shaker , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Safinaz Samy Ibrahim , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
