A study on the possible protective effects of curcumin and grape seed extract on male fertility of hypercholesterolemic rats / (Record no. 81892)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03429cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032807.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210829s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2021.Da.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dalia Kamal Abdulwahab |
| 245 12 - TITLE STATEMENT | |
| Title | A study on the possible protective effects of curcumin and grape seed extract on male fertility of hypercholesterolemic rats / |
| Statement of responsibility, etc. | Dalia Kamal Abdulwahab ; Supervised Noha Fawzy Hamed , Rania Awad Hassan |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة عن التأث{u٠٦أأ}رات المحتملة للكركم ومستخلص بذور العنب على خصوبة ذكور الجرذان ذات الكول{u٠٦أأ}ست{u٠٦أأ}رول العالى بالدم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Dalia Kamal Abdulwahab , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 112 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectives: Reduced male fertility is highly prevalent with hypercholesterolemia. Though statins are drugs of choice for hypercholesterolemia, their effect on male fertility is still controversial and dose-dependent. Some herbal remedies like grape seed extract (GSE) and curcumin possess hypocholesterolemic and testicular protective effects. Thus, this study aimed to investigate the protective effects of low-dose atorvastatin (ATV) on male infertility of hypercholesterolemic rats and to assess the additional value which could be obtained from combining ATV with either GSE or curcumin. Methods: Adult male Sprague dawley rats were randomized into unequal groups; rats of the first group (n=10) were fed a standard diet (SD) and served as the normal control, and rats of the second group (n=70) were fed a high-fat diet (HFD) for 30 days for induction of hypercholesterolemia. Hypercholesterolemic rats were then allocated into 7 groups 10 rats each; I- high-fat diet (HFD) group: rats were fed HFD and received no treatment and served as the positive control, II- CMC group: rats were fed HFD and administered 1% CMC and served as a control for rats treated with drugs suspended in CMC, III- ATV group: rats were fed HFD and treated with ATV (1mg/kg), IV- GSE group: rats were fed HFD and treated with GSE (200mg/kg), V- Curcumin group: rats were fed HFD and treated with curcumin (80mg/kg), VI- ATV+GSE: rats were fed HFD and administered both ATV and GSE, VII-ATV+curcumin: rats were fed HFD and administered both ATV and curcumin. Different treatments were orally administered for 65 days. Serum lipid profile parameters and testosterone level were measured. Sperm count, sperm motility, and fertility index were evaluated. Testicular content of MDA, NO, GSH, SOD as well as catalase enzyme activity were determined. In addition, testicular immunohistochemical expression of caspase-9 and -3 was estimated. Finally, histopathological examination of testes and seminal vesicles was performed |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Curcumin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Grape seed |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Male fertility of hypercholesterolemic rats |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Fawzy Hamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Awad Hassan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2021.Da.S | 01010110084030000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2021.Da.S | 01020110084030000 | 22.09.2023 | CD - Rom | 84030.CD |