Marine streptomycetes as a source of bioactive compounds against pathogenic bacteria : (Record no. 82052)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03357cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032813.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210911s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.07.06.Ph.D.2021.Ay.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ayatollah Samir Abdelmoniem Elzayat |
| 245 10 - TITLE STATEMENT | |
| Title | Marine streptomycetes as a source of bioactive compounds against pathogenic bacteria : |
| Remainder of title | an evolutionary view of antibiotic resistance / |
| Statement of responsibility, etc. | Ayatollah Samir Abdelmoniem Elzayat ; Supervised Ferial Mohamed Rashad , Hayam Mohamed Fathy , Mohamed Abdallah Moselhy Beshr |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الاستربتوميسيتات البحرية مصدر لإنتاج المركبات النشطة بيولوجياً ضد البكتريا الممرضة : |
| Remainder of title | دراسة تطور مقاومة المضادات الحيوية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ayatollah Samir Abdelmoniem Elzayat , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 182 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Agriculture - Department of Microbiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In response to the challenge and crisis of prevalence of multi-drug resistant pathogens, the major targets of the present study adopted two strategies and conducted in two parts. The major target of the first part was geared to explore a new bioactive metabolite from marine Streptomyces 10SAE while the other to steer and slow the evolutionary path of resistance using antibiotic adjuvant. The productivity and potency of the synthesized biomolecule(s) found to be medium and microorganism dependent. The optimum conditions for maximal productivity of bioactive metabolite using starch casein nitrate broth (SCNB) as reference medium simultaneously with shrimp shell (SS) as a monocomponent medium were as follow: 20% v/v loading volume, 2 or 3% v/v of 3-days old spores{u2019} suspension as inoculum size, agitation speed 180 rpm, initial pH 6.5-7.5 at 30 - 35{u00B0}C for 5 days.The highest productivity of bioactive compound(s) was achieved at gl-1: starch, 10; KNO₃, 2.0; casein, 0.3; K₂HPO₄, 2.5; MgSO₄.7H₂O, 0.5; FeSO₄.7H₂O, 0.01; NaCl, 5.0 and CaCO₃, 0.02.SS at 5.0 gl-1 proved its significance as a cheap suitable medium be better than or at least on par with SCNB. Antibacterial activity of the petroleum ether extract was more potent than crude filtrate. Minimum inhibition concentration (MIC) values of extract were generally lower than those obtained by reference antibiotics and minimum bactericidal concentration were 1- 4 folds of MIC values.The extract did not show any cytotoxic activity either against human tumor or normal cells up to 100 æg ml-1. All the separated purified fractions using the silica gel column chromatography gave single separated band with similar retention factor (Rf) value of 0.90 on TLC |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antimicrobial activity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bis (2- ethylhexadecyl) phthalate |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Marine Streptomyces |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ferial Mohamed Rashad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hayam Mohamed Fathy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Abdallah Moselhy Beshr , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.07.06.Ph.D.2021.Ay.M | 01010110084132000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.07.06.Ph.D.2021.Ay.M | 01020110084132000 | 22.09.2023 | CD - Rom | 84132.CD |