Molecular characterization of carbapenemases in lactose fermenters enterobacteriaceae isolates from Egyptian cancer patients / (Record no. 82120)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03356cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032815.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210914s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.06.Ph.D.2021.Di.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dina Mohamed Osama |
| 245 10 - TITLE STATEMENT | |
| Title | Molecular characterization of carbapenemases in lactose fermenters enterobacteriaceae isolates from Egyptian cancer patients / |
| Statement of responsibility, etc. | Dina Mohamed Osama ; Supervised Abdelgawad Hashem , Tarek Mansour , Ahmed Sherif Attia |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التوصيف الجزيئى للكاربابينيميزيز فى عزلات البكتيريا المعوية المخمرة لالكتوز المعزولة من مرضى السرطان المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Dina Mohamed Osama , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 143 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Healthcare-associated infections caused by antimicrobial-resistant microorganisms represent a major global threat. Thus, we aimed to evaluate two different molecular typing methods, to investigate the clonal relatedness for carbapenemase-producing Enterobacteriaceae strains that might contribute to a major hospital outbreak among high-risk patients. Gram-negative isolates were obtained from cancer patients. Bacterial isolates were identified using conventional and automated microbiological methods. Antimicrobial susceptibilities were determined using both disc diffusion method, however, minimum inhibitory concentration was determined by Vitek 2 and E-test. Phenotypic detection for carbapenemases producing isolates was performed. Detection for both carbapenemases and ESBLs encoding genes by PCR and DNA sequencing. Klebsiella pneumoniae was the most prevalent among other Enterobacteriaceae isolates.Thus, it was selected for clonal relationship determination especially for those isolates that harbour blaOXA-48 gene. Clonal relatedness was performed using both Enterobacterial repetitive intergenic consensus (ERIC)-PCR and pulsed-field gel electrophoresis (PFGE).The blaOXA-48 was the most common gene compared to, blaNDM-1, blaIMP and blaVIM genes in the carbapenem resistant (CR) isolates. However, blaTEM was prevalent among ESBLs genes compared to blaCTX-M and blaSHV were identified. Some of the carbapenem resistant Enterobacteriaceae (CRE) isolates co-harboured at least 2 different resistant determinates. Dendrogram analysis for ERIC and PFGE genotyping revealed 3 possible related clones harbouring blaOXA-48 gene with similarity coefficient {u2265}85%, respectively.The study findings underlined an increased circulation of some closely related clones of multidrug-resistant K. pneumoniae harbouring carbapenem resistance determinants |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Carbapenemase-producing Enterobacteriaceae |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Clonal relatedness |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pulsed-field gel electrophoresis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelgawad Hashem , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Sherif Attia , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek Mansour , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.06.Ph.D.2021.Di.M | 01010110084177000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.06.Ph.D.2021.Di.M | 01020110084177000 | 22.09.2023 | CD - Rom | 84177.CD |