MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03433cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
210919s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.09.08.Ph.D.2021.Ah.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Adel Mohamed Abdelazim |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Cancer chemoprevention by Metformin Hydrochloride compared to placebo in oral potentially malignant lesions : |
| Remainder of title |
A randomized clinical trial (part I) / |
| Statement of responsibility, etc. |
Ahmed Adel Mohamed Abdelazim ; Supervised Fat{u2019}heya Mohamed Zahran , Gihane Gharib Madkor , Heba Ahmed Farrag |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
الوِقايَةٌ الكِيمْيائِيَّة من السرطان بواسطة هيدروكلوريد الميتفورمن مقارنة بالغُفْل في آفات الفم القابلة للتسرطن : |
| Remainder of title |
دراسة إكلينيكيّة على عينات مختارة عشوائياً - الجزء الأول |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ahmed Adel Mohamed Abdelazim , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
201 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Aim: The aim of this study was to compare the effect of metformin hydrochloride on potentially malignant to placebo regarding its efficacy in regression or suppression of the progress into frank cancer. Methodology: This trial was a multicentre, triple{u00AD}blind, placebo{u00AD}controlled, randomized phase II trial. 40 non{u00AD}diabetic adult patients clinically and histologically diagnosed with OPMD were enrolled into the study. Eligible patients were randomly assigned (1:1) to receive oral met{u00AD} formin (500 mg daily) or identical placebo tablets by a stratified computer{u00AD}based randomization method for a duration of 3 months. All patients, clinicians, and outcome assessors were masked to drug allocation until the end of the trial. Recommended standard health and dental care were given to both groups.Clinical data, biopsies, immunohistochemical staining of cyclin D1, and RT{u00AD}qPCR quantification of tissue and salivary miRNA{u00AD}21 were performed for all groups at baseline and at three months point. Results: The current study showed that metformin was effective as a cancer chemopreven{u00AD} tive agent in controlling some of the molecular mechanisms that could lead to the the malignant transformation of OPMDs. Clinical lesion size, nuclear expression of cyclin D1, and tissue and salivary levels of cancer{u00AD}associated miRNA{u00AD}21 showed a statistically significant reduction in the metformin group compared to the placebo group. Cyclin D1 and miRNA{u00AD}21 correlated well to the degree of epithelial dysplasia, while toluidine blue color intensity was of limited value as a prognostic aid in OPMD. miRNA{u00AD}21 demonstrated a positive correlation between tissue and saliva levels, highlighting the emerging role of salivary transcriptomics in the field of OPMDs and oral cancer |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Cancer chemoprevention |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Metformin Hydrochloride |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Potentially malignant |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Fat{u2019}heya Mohamed Zahran , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Gihane Gharib Madkor , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Heba Ahmed Farrag , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
