MARC details
| 000 -LEADER |
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| fixed length control field |
02420cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
211005s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.08.03.M.Sc.2021.Em.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Eman Mohamed Moaaz Mohamed Emara |
| 245 10 - TITLE STATEMENT |
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| Title |
Analytical studies on some prodrugs / |
| Statement of responsibility, etc. |
Eman Mohamed Moaaz Mohamed Emara ; Supervised Ezzat Mohamed Abdelmoety , Mamdouh Reda Rezk , Ahmed Salah Fayed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسات تحليلية على بعض الأدوية الأولية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Eman Mohamed Moaaz Mohamed Emara , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
143 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
This thesis is concerned with the quantitative determination of some prodrugs. In this thesis, two prodrugs (tedizolid phosphate and acemetacin) were studied separately as targeted analytes. The first prodrug, tedizolid phosphate, is an antibiotic that is bio-activated to tedizolid by phosphatase enzymes.The second drug, acemetacin, is an analgesic non-steroidal anti-inflammatory drug that is bio-activated to indomethacin by liver enzymes.The aim of this work was to develop different analytical methods which are characterized by simplicity, accuracy and appropriate degree of sensitivity for the analysis of the above-mentioned prodrugs in their powdered form, in the presence of dosage-form excipients, active metabolites and possible degradation products. Two stability-indicating chromatographic methods, simple fluorimetric and ion selective electrode based potentiometric methods were developed for the sensitive analysis of tedizolid phosphate.Tedizolid was confirmed to be the major degradant of tedizolid phosphate obtained by simple neutral degradation of the parent drug. Acemetacin was assayed by different chromatographic, fluorimetric and electrochemical (voltammetry and ion selective electrode) methods |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Acemetacin |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Chromatographic |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Methods |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Salah Fayed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ezzat Mohamed Abdelmoety , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mamdouh Reda Rezk , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
