Design, synthesis and biological evaluation of novel benzimidazoles / (Record no. 82462)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02313cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032825.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211005s2021 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2021.Sa.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sarah Hammad Mohamed Khairat |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and biological evaluation of novel benzimidazoles / |
| Statement of responsibility, etc. | Sarah Hammad Mohamed Khairat ; Supervised Fatma Abdelfttah Ragab , Hoda Ibrahim Eldiwani |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التصميم و التشييد و التقييم البيولوجى للبنزيميدازولات الجديده |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sarah Hammad Mohamed Khairat , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 158 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present investigation deals with the synthesis of pyrazolylbenzimidazoles with bi substituents at both the benzimidazole and pyrazole moieties. All the synthesized compounds were tested for their ability to inhibit Sphingosine-1 kinase (SphK-1) which promotes tumor growth and is considered as a novel approach for treatment of cancer. Most of the tested compounds showed good percentage of inhibition. In addition, fluorescence binding studies of all the synthesized compounds was performed and compounds130,131, 138, 142, 144, 146,147, 148 and 150 revealed the formation of a stable protein-ligand complex. The IC50 of the nine compounds were calculated. In addition, the antiproliferative activity against 60 different cell lines were determined by NCI Development therapeutic program and the results showed that these compounds showed good inhibition percentage against different cell lines. Finally, molecular docking study was performed in the active site of SphK-1 to elucidate the mode of interaction |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Biological evaluation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Novel benzimidazoles |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sphingosine-1 kinase (SphK-1) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fatma Abdelfttah Ragab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Ibrahim Eldiwani , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2021.Sa.D | 01010110084365000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2021.Sa.D | 01020110084365000 | 22.09.2023 | CD - Rom | 84365.CD |