Study of the potential effect of low-dose gamma radiation against cyclophosphamide-induced myelosuppression and cardiotoxicity in rats : (Record no. 82561)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03134cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032828.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211013s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2021.Am.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amira Abdelraouf Mohammed |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the potential effect of low-dose gamma radiation against cyclophosphamide-induced myelosuppression and cardiotoxicity in rats : |
| Remainder of title | Code PO 347 / |
| Statement of responsibility, etc. | Amira Abdelraouf Mohammed ; Supervised Hesham A. Salem , Nour Eldin A. Mohammed , Mohammed F. Elyamany |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة التأثير المحتمل لجرعة منخفضة من اشعة جاما ضد تثبيط نخاع العظم و سمية القلب المحدث بسيكلوفوسفاميد فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amira Abdelraouf Mohammed , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 119 P . : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cyclophosphamide (Cyp) is one of the most commonly used, wide spectrum chemotherapeutic agents. It is mostly used in combinations although it is solitarily efficient, this is because the side effects that follow its administration are dose limiting side effects. On the other hand, although radiation is well known as a hazardous sort of energy, recent studies are interested in studying the beneficial hormetic effect of low doses of gamma radiation. In this study we examined the protective effect of different doses, dose rates, and dose timings of low dose gamma irradiation against Cyp-induced neutropenia. As well as the effect of two different doses/dose rates of gamma irradiation against cyp-induced cardiotoxicity. For neutropenia models, rats were divided into groups for screening of an effective protective dose. For cardiotoxicity tests, rats were divided into seven groups; group 1 served as control group, group 2 served as the model receiving 200 mg/Kg cyp single i.p. dose, group 3 was subjected to low dose rate (LDR) 0.05 gy of irradiation prior to the cyp dose, group 4 was subjected to high dose rate (HDR) 0.25 gy of irradiation prior to the cyp dose, group 5 received total 70 mg/Kg of telmisartan prior to the cyp dose, group 6 received telmisartan dose and 0.05 Gy LDR prior to the cyp, and group 7 received telmisartan dose and 0.25 Gy HDR prior to the cyp dose. Evaluation of this study was based on the effect of cyp on the heart Tn-1 and LDH. As well as examining NF-mB activation pathways; by assaying the content of p65, ImB, IKK-Ü and IKK-ß in the heart muscle using western blot technique |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cardiotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cyclophosphamide |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Irradiation dose |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hesham A. Salem , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed F. Elyamany , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nour Eldin A. Mohammed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2021.Am.S | 01010110084411000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2021.Am.S | 01020110084411000 | 22.09.2023 | CD - Rom | 84411.CD |