Stem cell therapy of male rat reproductive toxicity : (Record no. 82614)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02845cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032830.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211017s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2021.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Maha Abdelhamid Mohamed Salem |
| 245 10 - TITLE STATEMENT | |
| Title | Stem cell therapy of male rat reproductive toxicity : |
| Remainder of title | Potential cross-talk between endocrine disruption and carnitine deficiency / |
| Statement of responsibility, etc. | Maha Abdelhamid Mohamed Salem ; Supervised Aiman S. Elkhatib , Hossam M. M. Arafa , Hala F. Zaki |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التداخل المحتمل بين الخلل الصماوى ونقص الكارنتين : |
| Remainder of title | علاج السمية الإنجابية فى ذكورالجرذان بإستخدام الخلايا الجذعية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Maha Abdelhamid Mohamed Salem , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 267 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | We have addressed in the current study the potential role of either Lcarnitine (LC) or MSCs to extenuate the reproductive toxic insults of carbendazim (CBZ) in Swiss albino male rats as well as the molecular mechanisms whereby these interventions would modify the spermatogenic and steroidogenic derangements invoked by the endocrine disruptor. Herein, animals received subchronic daily doses of carbendazim (100 mg/kg) by gavage for 8 weeks. CBZ-challenged animals were co-supplemented with LC (500 mg/kg, IP) twice weekly for 8 weeks or MSCs (3 x 106 cells (IV) in 0.1 ml phosphate buffer saline) once two weeks before the end of the experiment. Sperm quantity and quality (morphology, motility and viability), serum testosterone and gonadotropins, inhibin B and thyroid hormone levels were assessed. Serum tumor necrosis alpha (TNF-Ü), interleukin-6 (IL-6) and interleukin-10 (IL-10) concentrations were determined by ELISA. Oxidant/anti-oxidant status in rat testis was investigated via measuring testicular contents of malonedialdehyde (MDA) and reduced glutathione (GSH), as well as the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Immunohistochemical localizations of the junctional protein; occludin, and inflammatory markers; inducible nitric oxide synthase (iNOS) and nuclear factor kappa beta (NF- {uF06B}B) were further analyzed |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Carbendazim |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Carnitine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mildronate |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala F. Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hossam M.M. Arafa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | iman S. Elkhatib , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2021.Ma.S | 01010110084437000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2021.Ma.S | 01020110084437000 | 22.09.2023 | CD - Rom | 84437.CD |