Design, synthesis and molecular modeling study of some novel pyrazole derivatives as potential anticancer agents / (Record no. 82624)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02765cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032830.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211017s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2021.Es.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Esraa Zakaria Mohammed Ragab |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and molecular modeling study of some novel pyrazole derivatives as potential anticancer agents / |
| Statement of responsibility, etc. | Esraa Zakaria Mohammed Ragab , Supervised Ghaneya Sayed Hassan , Hanan Hanna Georgey , Riham François George |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد ودراسة النمذجة الجزيئية لبعض مشتقات البيرازول الجديدة ذات فاعلية محتملة كمضادات للأورام |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Esraa Zakaria Mohammed Ragab , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 207 P . : |
| Other physical details | charts , facsmilIes ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cancer represents one of the main death causes worldwide. Despite the indispensable progress accomplished in cancer treatments, several limitations still exist. Subsequently, the innovation of novel small molecules that are both potent and selective remains a serious challenge to medicinal chemists. This thesis deals with the design and synthesis of some novel pyrazole and pyrazolopyridine derivatives which were evaluated as anticancer agents. In vitro CDK2 enzyme inhibition assay was carried out for all the final compounds. Selectivity profile against a panel of other CDKs isoforms (CDK1, CDK4 and CDK7) was studied for the most promising compounds. Additionally, the uppermost active compounds were investigated for further mechanistic investigation; cell cycle analysis, apoptotic assay, and safety profile assessment. Molecular docking study was carried out to predict the possible binding mode of the newly synthesized compounds with the CDK2 ATP binding site in a trial to explain their observed activity. Moreover, a 2D QSAR model revealed the structural characteristics governing the CDK2 inhibition activity of our target pyrazolopyridine derivatives. Finally, ADMET computational study predicted the pharmacokinetic aspects and toxicity risks for the studied compounds |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anticancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diphenyl-1H-pyrazoles |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | pyrazolo[3,4-b]pyridines |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghaneya Sayed Hassan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Hanna Georgey, |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Riham François George , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2021.Es.D | 01010110084440000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2021.Es.D | 01020110084440000 | 22.09.2023 | CD - Rom | 84440.CD |