Studying the effect of Synadenium grantii branches and leaves extract (s) In vitro and as chemopreventive and anti-cancer agents in Benzo(a) Pyrene-induced lung cancer in rats / (Record no. 83167)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02892cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032848.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211115s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2021.Mo.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Fawzy Ibrahim Ahmed Barghash |
| 245 10 - TITLE STATEMENT | |
| Title | Studying the effect of Synadenium grantii branches and leaves extract (s) In vitro and as chemopreventive and anti-cancer agents in Benzo(a) Pyrene-induced lung cancer in rats / |
| Statement of responsibility, etc. | Mohamed Fawzy Ibrahim Ahmed Barghash ; Supervised Mahmoud Mohamed Khattab , Rania Mohsen Abdelsalam , Mai Afifi Mohamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تأثير مستخلصات فروع وأوراق نبات السينادينيام جرانتى معمليا وكعوامل مضادة لسرطان الرئة المستحث بالبنزو (أ) بيرين فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Fawzy Ibrahim Ahmed Barghash , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 190 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | One of the most lethal cancers of the 20th century is lung cancer which is causing up to 3 million deaths annually worldwide.Therefore, management of lung cancer needs searching for new chemopreventive agents. This work was designed to inspect the chemopreventive potential of Synadenium grantii extracts on lung carcinogenicity induced by Ben-zo(a)pyrene [B(a)P] in male albino western rats. This target was undertaken through preparing different extracts (water, methanol, ethanol and chloro-form) from branches and leaves of S. grantii for screening their effect on lung cancer cell line (A549), then the most active extract was used for com-bating lung cancer in animal model. The in vitro results revealed that, the methanolic extract was found to be the most active extract against A549 cells. The methanolic extract of S. grantii has a notable cytotoxicity activity (IC50: 4.30±0.44 og/ml) against A549 cells more than the other extracts and its activity was close to the cytotoxicity of standard drug, doxorubicin (IC50: 3.50±040 og/ml) due to the presence of high flavonoids content. After the determination of S. grantii safe dose (305mg/Kg b.w.), which represents 1/10 of lethal dose, in the in vivo experiment, rats were divided into five groups (10 animal each) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cytotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lung cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Synadenium grantii |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Mohamed Khattab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mai Afifi Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Mohsen Abdelsalam , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2021.Mo.S | 01010110084759000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2021.Mo.S | 01020110084759000 | 22.09.2023 | CD - Rom | 84759.CD |