Evaluation of the effects of sucralose or saccharine / cyclamate mixture administration in albino mice / (Record no. 83204)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02858cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032849.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211120s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2020.Ge.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gehad Assem Hassan |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of the effects of sucralose or saccharine / cyclamate mixture administration in albino mice / |
| Statement of responsibility, etc. | Gehad Assem Hassan ; Supervised Alyaa Ahmed Farid Ahmed , Neveen Adel Madbouly |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم آثار إعطاء السكرلاوز او خليط من السكارين/ السيكلامت فى الفئران البيضاء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Gehad Assem Hassan , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 84 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Sucralose and saccharin-cyclamate mixture are considered safe commercial artificial sweeteners with many health authorities instead of natural sugar. We aimed to reveal their effects on the physiological, immunological and histological profiles in vivo. Mice were given sucralose (0.3 mg/ml) or saccharin-cyclamate mixture (20 mg/ml) in drinking water for 8 and 16 weeks. Only sucralose caused a temporary significant increase in blood glucose after 8 weeks that ended after 16 week. Hematological studies showed that WBCs count was decreased significantly at 16 weeks of sucralose administration (long-term effect). Liver and kidney functionalities showed that AST, ALT, urea and creatinine recorded an increase at 8 and 16 weeks of two artificial sweeteners intake. For Immunological parameters both artificial sweeteners induced a significant increase in IL-6, TNF-Ü and LPS levels with a progress from 8th to 16th weeks post administration. Histological sections showed that both sugars, especially sucralose, caused a severe damage in kidney, liver, pancreas and urinary bladder. Data indicated the adverse effect of both sweeteners. Artificial sweeteners as sucralose, saccharine and cyclamate should be avoided. Their consumption can cause a severe inflammation in liver, kidney, pancrease and urinary bladder.These artificial sweeteners pass across alimentary canal without being digested and change microbiota composition and function. Moreover, they are disturbing intestinal barriers leading to an increase in circulating LPS and pro-inflammatory cytokine secretions |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IL-6 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Saccharin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sodium cyclamate |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alyaa Ahmed Farid Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Neveen Adel Madbouly , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2020.Ge.E | 01010110084767000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2020.Ge.E | 01020110084767000 | 22.09.2023 | CD - Rom | 84767.CD |