The possible neuroprotective effects of certain antihypertensive drugs in cuprizone model of multiple sclerosis in mice / (Record no. 83225)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03339cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032849.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211121s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2021.Am.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amira Emad Abdelziz |
| 245 14 - TITLE STATEMENT | |
| Title | The possible neuroprotective effects of certain antihypertensive drugs in cuprizone model of multiple sclerosis in mice / |
| Statement of responsibility, etc. | Amira Emad Abdelziz ; Supervised Nesrine Salah Eldin , Rabab Hamed Sayed , Nada A. Sallam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة الآثار الوقائية المحتملة لبعض الادوية المضادة لارتفاع ظغط الدم فى نموذج كوبريزون للتصلب المتعدد على الأعصاب فى الفئران |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amira Emad Abdelziz , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 128 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Multiple Sclerosis is a chronic inflammatory neurodegenerative disease of the central nervous system which injures the myelin sheath.Telmisartan and nifedipine are antihypertensive drugs that recently showed neuroprotective properties against neurodegenerative diseases.This study evaluated the neuroprotective effect of telmisartan or nifedipine in cuprizone-induced demyelination in mice with examining the underlying mechanisms. C5B7/6 mice received a diet containing 0.7% (w/w) cuprizone for 7 days followed by 3 weeks on 0.2% cuprizone diet.Telmisartan (5 mg/kg/day, p.o.) or nifidipine (5 mg/kg/day, p.o.) were given for 3 weeks starting from the second week. Telmisartan or nifidipine improved locomotor activity and enhanced motor coordination as demonstrated by open field, rotarod and grip strength tests. Furthermore, treatment with telmisartan or nifedipine resulted in the restoration of myelin basic protein mRNA and protein expression and the increase in Luxol Fast Blue-staining intensity. Telmisartan or nifedipine attenuated cuprizone-induced oxidative stress and apoptosis by decreasing brain malondialdehyde and caspase-3 along with restoring reduced glutathione and brain derived neurotrophic factor levels.Telmisartan or nifidipine exerted an anti-inflammatory effect by reducing the expression of nuclear factor kappa B (NF-mB p65) as well as proinflammatory cytokines and elevating the expression of ImB-Ü. In parallel, telmisartan or nifedipine upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and the levels of heme oxygenase-1 and NADPH quinone oxidoreductase1 enzymes. In conclusion, the current study provides evidence for the protective effect of telmisartan and nifedipine in cuprizone-induced demyelination and behavioural dysfunction in mice possibly by modulating NF-mB and Nrf2 signalling pathways |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cuprizone |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Demyelination |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Multiple sclerosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nada A. Sallam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nesrine Salah Eldin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rabab Hamed Sayed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2021.Am.P | 01010110084780000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2021.Am.P | 01020110084780000 | 22.09.2023 | CD - Rom | 84780.CD |