Preparation and evaluation of nanovesicles containing an anti-cancer herbal drug / (Record no. 83274)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02710cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211124s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.M.Sc.2021.Ya.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yasmeen Nader Mohamed Ezzeldeen |
| 245 10 - TITLE STATEMENT | |
| Title | Preparation and evaluation of nanovesicles containing an anti-cancer herbal drug / |
| Statement of responsibility, etc. | Yasmeen Nader Mohamed Ezzeldeen ; Supervised Aliaa Nabil Ahmed Elmeshad , Shady Aly Swidan Elkhouriby |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير وتقييم الحويصلات النانوية المحتوية على دواء عشبى مضاد للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Yasmeen Nader Mohamed Ezzeldeen , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 102 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Honokiol (HK) is a bioactive natural compound with proven antineoplastic properties against melanoma. However, HK shows very low bioavailabilitywhen administered orally. Alternatively, topical administration may offer a promising route, but is still challenging owing to the presence of physiological barriers, which are: the stratum corneum, the anomalous tumor microenvironment (TME) and itsinterstitial matrix. Herein, our objective was to fabricate HK loaded transfersomes (HKT) to enhance the HK bioavailability and to overcome these barriers and to enhance the topical drug delivery for melanoma treatment. Transfersomes (TFs) were prepared using the modified scalable heating method without using any organic solvents. The influence of the three fabrication variables: the loading drug amount, the stirring speed, and the speed of homogenization on the transfersomal particle size (PS), polydispersity index (PDI), zeta potential (ZP) and HK entrapment efficiency (EE) were assessed. It was found that the speed of homogenization exhibited a significant effect on the PS, PDI, ZP, and HK EE; while the stirring speed revealed a significant effect on the PS; and the loading drug amount affected the PDI and the HK EE. Surface response optimization was applied for the three process factors in order to select the optimized formula that was successfully prepared showing a small mean PS, a highly negative surface charge , and a high EE . |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anti-cancer herbal drug |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Microenvironment (TME) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanovesicles |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aliaa Nabil Ahmed Elmeshad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shady Aly Swidan Elkhouriby , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.M.Sc.2021.Ya.P | 01010110084820000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.M.Sc.2021.Ya.P | 01020110084820000 | 22.09.2023 | CD - Rom | 84820.CD |