Comparative hepatoprotective efficacy of some anti-oxidants and prebiotics on experimentally induced hepatic fibrosis in rats / (Record no. 83299)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03518cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032852.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211127s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.15.Ph.D.2021.Ze.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Zeinab Adel Mahmoud Elgendy |
| 245 10 - TITLE STATEMENT | |
| Title | Comparative hepatoprotective efficacy of some anti-oxidants and prebiotics on experimentally induced hepatic fibrosis in rats / |
| Statement of responsibility, etc. | Zeinab Adel Mahmoud Elgendy ; Supervised Salah Eldin Abdelhamid Youssef , Amer Ramadan Ali Ayad , Seham Abdelsatar Elbatran |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة مقارنة عن الفعالية الوقائية لبعض مضادات الأكسدة والبريبيوتكس على التليف الكبدى المستحدث تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Zeinab Adel Mahmoud Elgendy , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 81 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Fibrosis represents a common outcome of almost all chronic liver diseases and leads to an impairment of liver function that requires medical intervention. The current study aimed at evaluating the potential anti- fibrotic activity of saccharomyces cervisciae cell wall extract (SCCWE) and carvacrol against thioacetamide (TAA)-induced liver fibrosis in rats (200mg/ kg b.w. i.p. twice weekly for 6 weeks) using ursodeoxycholic acid (UDCA) (20 mg/kg p.o.) as a reference anti-fibrotic product. SCCWE at two doses (50 and 100 mg/kg) and carvacrol at two doses (25 and 50 mg/ kg p.o.) significantly ameliorated the rise in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamide transferase (GGT), total bilirubin (TB) and direct bilirubin (DB) and increased total protein (TP) and albumin level. SCCWE significantly reduced glutathione depletion (GSH), nitric oxide (NOX) and malondialdehyde (MDA) accumulation in liver tissue. Its anti-oxidant effects appeared by affecting markers of stress found in the cell as nuclear erythroid factor -2 (Nrf-2) by significantly restoring its content. Its anti-inflammatory effects were confirmed by observing the decreasing of nuclear factor-кB (NF-кB), interleukin-1Ý (IL-1Ý) and inducible nitric oxide synthetase (iNOS) content. The anti-fibrotic effects of them were explored by assessing fibrosis related markers as they significantly reduced autotaxin (ATX), transforming growth factor Ý (TGF-Ý) and thioredoxin (Trx). Their administration significantly decreased matrix metalloproteinase-3 and 9 (MMP-3 and 9). Furthermore, they also decreased alpha smooth muscle actin (Ü-SMA) and caspase-3 as assessed immunohistochemically those results were similar to that of the standard drug UDCA. Overall result showed that SCCWE and carvacrol protect against TAA-induced liver fibrosis in rats, so they can be ascribed as a protecting natural materials from liver fibrosis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Liver {uFB01}brosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxidative stress |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SCCWE |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amer Ramadan Ali Ayad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salah Eldin Abdelhamid Youssef , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Seham Abdelsatar Elbatran , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.15.Ph.D.2021.Ze.C | 01010110084835000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.15.Ph.D.2021.Ze.C | 01020110084835000 | 22.09.2023 | CD - Rom | 84835.CD |