Topical sustainable ophthalmic nanoparticle drug delivery systems for improving the treatment of cataract / (Record no. 83556)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03025cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211213s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2021.Ru.T |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ruddy Moneer Abdalrahman |
| 245 10 - TITLE STATEMENT | |
| Title | Topical sustainable ophthalmic nanoparticle drug delivery systems for improving the treatment of cataract / |
| Statement of responsibility, etc. | Ruddy Moneer Abdalrahman ; Supervised Alya Abalateef Badawy , Magdy Ibrahim Mohammed , Rawia Mohamed Khalil |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | صياغات عينية موضعية نانومترية ممتدة المفعول لتحسين علاج إعتام عدسة العين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ruddy Moneer Abdalrahman , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 167 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cataract is an opacification of all or specific regions of the lens that results in obstruction of light and gradual loss of vision. It continues to be the leading cause of blindness worldwide, accounting for over 50% of the world{u2019}s blind population.The underlying causes of cataract are quite diverse with the majority of cataracts acquired after middle age. Congenital or juvenile cataracts, considered as early onset cataracts, are less common but nonetheless have significant visual consequences.L-Carnosine (b-alanyl-L-histidine) is generally found in milli-Mole (mM) concentrations in several mammalian tissues, potentially exhibiting different metabolic activities. The previously published data suggest that L-carnosine has excellent potential to act as a natural antioxidant with hydroxyl radical, singlet oxygen scavenging and lipid peroxidase activities. A striking effect of L-carnosine is its demonstrated ability to prevent, or partially reverse, lens cataract. The N-acetyl derivative of carnosine (NAC) of carnosine exists in the cardiac and skeletal mammalian muscles and the total concentration of these imidazoles may lie within the measured range of L-carnosine in skeletal muscle.The advantage of NAC to act as an in vivo universal antioxidant with physiological and therapeutic relevance deals with its ability to give efficient protection against oxidative stress in the lipid phase of biological membranes and in aqueous environment due to turnover into L-carnosine. Due to its relative hydrophobicity compared with L-carnosine, NAC might penetrate through the cornea gradually, thus maintaining longer the active therapeutic concentration of L-carnosine in aqueous humor of the treated eye |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cataract |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cyclodextrin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanosponge |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alya Abalateef Badawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ibrahim Mohammed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rawia Mohamed Khalil , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2021.Ru.T | 01010110084981000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2021.Ru.T | 01020110084981000 | 22.09.2023 | CD - Rom | 84981.CD |