The possible neuroprotective effectof vortioxetine against cerebral ischemia-reperfusion inducedin rats / (Record no. 83558)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02946cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032900.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211214s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2021.Am.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amr Mohamed Emam Mohamed |
| 245 14 - TITLE STATEMENT | |
| Title | The possible neuroprotective effectof vortioxetine against cerebral ischemia-reperfusion inducedin rats / |
| Statement of responsibility, etc. | Amr Mohamed Emam Mohamed ; Supervised Hala Fahmy Zaki , Naglaa Assaf , Muhammed Abdullatif |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير المحتمل الواقى للأعصاب لعقار الفورتيؤكستين ضد إفقار الدم بالمخ وإعادة التروية المحدث فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amr Mohamed Emam Mohamed , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 147 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Stroke has grown to the fifth and third leading causes of death, respectively, in the U.S and the rest of the world. Vortioxetine (VTX) is a multimodal antidepressant agent that balances 5-HT receptors and represses the serotonin transporter.The purpose of this research was to investigate if VTX protects against cerebral ischemia induced by occluding the middle cerebral artery (MCA). VTX (10 mg/kg/day) was administered orally for14 days prior to the onset of the middle cerebral artery occlusion (MCAO). Behavioral assessments were carried out 24 hours after the MCAO technique.The hippocampal and cortical tissues of the brain were isolated to assess the histological changes and the levels of the biochemical parameters.Damage from MCAO resulted in significant neurological impairments as well as histopathological damage. VTX, on the other hand, alleviated MCAO-induced neurological impairments and histological abnormalities in both hippocampus and cortical tissues of ischemic rats. Western blot analysis indicated significant rises of p-PERK, CHOP, ASK-1, NICD, HES-1, HES-5, and p-eIF2Ü expression levels in MCAO rats. Moreover, ELISA revealed an increase in the levels of ATF4, IRE1, Apaf-1, and HIF-1Ü, while VTX administration ameliorated most of these perturbations induced after MCAO injury. This research suggests that VTX could be a potent neuroprotective agent against ischemic stroke by inhibiting a variety of oxidative, apoptotic, inflammatory, and endoplasmic reticulum stress pathways |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ischemic stroke |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | PERK/eIF2alpha/ATF4/CHOP |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vortioxetine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Muhammed Abdullatif , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naglaa Assaf , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2021.Am.P | 01010110084985000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2021.Am.P | 01020110084985000 | 22.09.2023 | CD - Rom | 84985.CD |