Role of a 5-hydroxytryptamine 3 receptor antagonist in the modulation of experimentally-induced neuroinflammation in rats (PO.3.4.3) / (Record no. 83704)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02639cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032904.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211226s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2021.Re.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reem Ali Mohamed Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Role of a 5-hydroxytryptamine 3 receptor antagonist in the modulation of experimentally-induced neuroinflammation in rats (PO.3.4.3) / |
| Statement of responsibility, etc. | Reem Ali Mohamed Ali ; Supervised Dalaal M. Abdallah , Hanan S. Elabhar , Amany Elbrairy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | (PO.3.4.3)دور احد مضادات مستقبل٥- هيدروكسى تريبتامين٣ فى تعديل الالتهابات العصبية المحدثة تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reem Ali Mohamed Ali , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 142 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Since westernized diet-induced insulin resistance is a risk factor in Alzheimer's disease (AD) development and lipopolysaccharide (LPS) coexist with amyloid Ý (AÝ)1-42 in these patients, our novel AD model was developed to resemble sporadic AD by injecting LPS to high fat/fructose diet (HFFD)-fed rats as a source of damage-associated molecular patterns. Our aim was to evaluate the neuroprotective potential of palonosetron, a 5-hydroxytrymptamine (5-HT)-3 antagonist, and the possible involvement of Ü7 nicotinic ACh receptors (nAchR) in palonosetron{u2019}s effects. Animals were allocated into control and HFFD/LPS untreated or treated groups. Palonosetron and/or methyllycaconitine (MLA), Ü7nAchR blocker, were given for 8 days, starting 3 h after LPS and MLA was injected 15 min before each palonosetron dose. All regimens improved histopathological findings and enhanced spatial memory (Morris water maze); however, palonosetron alone or with methyllycaconitine promoted animal performance during novel object recognition test. In the hippocampus, all regimens skewed microglia M1 to M2 phenotype indicated by the decreased M1 markers and the enhanced M2 related parameters |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 5-HT3 receptor blocker |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Inflammasomes |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyroptosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amany Elbrairy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalaal M. Abdallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan S. Elabhar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2021.Re.R | 01010110085070000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2021.Re.R | 01020110085070000 | 22.09.2023 | CD - Rom | 85070.CD |