MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03023cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
211226s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.05.M.Sc.2021.Es.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Esraa Abdelsalam Ahmed Radi |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Development, validation, and application of extraction solvent prediction models for different drugs from aqueous-based matrices / |
| Statement of responsibility, etc. |
Esraa Abdelsalam Ahmed Radi ; Supervised Asmaa Ahmed Elzaher , Ehab Farouk Elkady , Eman Adel Mostafa Saleh |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تطوير والتحقق من صحة وتطبيق نماذج للتنبؤ بالمذيبات العضوية لاستخراج الأدوية المختلفة من الوسائط المائية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Esraa Abdelsalam Ahmed Radi , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
88 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Biological matrix represents a challenge in extraction and bioanalysis due to the variability of extraction power and efficiency of solvents, cumbersome multi-step procedures, and usage of many organic solvents which is harmful to the environment. One of the most effective techniques for isolating the desired components from the biological matrix is liquid-liquid extraction. An optimized Artificial Neural Network model was developed based on correlating the selected descriptors of the drugs and Hansen solubility parameters for the predicted extraction solvents. Besides, the prediction power of the developed algorithm has been evaluated. This model was designed on MATLAB program as an ANN linear layer network, with a set of given input drug descriptors; providing outputs of corresponding Hansen solubility parameters for predicted extraction solvents. The model was applied to ten drugs from different pharmacological classes including drugs acting on Central Nervous System, Cardiovascular System, Gastrointestinal tract, Antihistaminic, Antiviral, Antibacterial, and Anti-diabetic classes. The evaluated drugs are Chlorpheniramine maleate, Donepezil, Escitalopram, Levofloxacin, Linagliptin, Nebivolol, Omeprazole, Sertraline,Telmisartan, and Valacyclovir. HPLC-UV methods were applied for the quantitative determination of the extracted drugs. The extraction recoveries of the studied drugs using the predicted solvents are (94%, 66%, 86%, 61%, 90%, 87%, 98%, 91%, 52%, and 92%) respectively. The developed model is deemed very useful in bioanalysis in terms of saving cost and time |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Artificial neural networks |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Extraction recovery |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Liquid-liquid extraction |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Asmaa Ahmed Elzaher , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ehab Farouk Elkady , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Eman Adel Mostafa Saleh , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
