MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02311cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
211227s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.12.21.Ph.D.2021.Re.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Reem Mahmoud Mohammad Mebed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Effect of Wnt/Ý-catenin pathway alteration in hepatocellular carcinoma cell lines and the possible modulation by bevacizumab / |
| Statement of responsibility, etc. |
Reem Mahmoud Mohammad Mebed ; Supervised Salwa Farouk Sabet , Nahla Shehata Kotb |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تاثير تغيير مسار الونت بيتا كاتينين على خطوط خلايا سرطان الكبد البشرى والتحوير المحتمل بواسطة البيفاسيزوماب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Reem Mahmoud Mohammad Mebed , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
89 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
As about 90% of colorectal cancers and 50% of hepatocellular carcinoma have activated Wnt/Ý-catenin signaling, the current study aim to examine the effect of knocking down Ý-catenin on the expression of VEGF-A and Slug as well as the apoptosis related genes; NF-mB, FasR and c-Flip in HepG2 cells and the possible alteration of their expression when combined with Bevacizumab. Expression of VEGF-A and Slug was also studied in Caco-2 cells. It is reported in this study that VEGF-A increases significantly in response to Bevacizumab alone in HepG2, while VEGF-A and Slug decreased significantly when Bevacizumab was combined with knocked down Ý-catenin in HepG2. However, Bevacizumab alone is more effective in reducing the expression of those genes in Caco-2. On the other hand, Bevacizumab combined with knocked down Ý-catenin remarkably reduced the level of NF-mB, FasR and c-Flip compared to Bevacizumab only treated HepG2 cells although the difference was not statistically significant |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Bevacizumab |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
VEGF |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Wnt/Ý-catenin |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nahla Shehata Kotb , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Salwa Farouk Sabet , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
