Preparation, characterization and evaluation of novel nanoemulsions in photodynamic therapy / (Record no. 83750)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03241nam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032906.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220101s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.24.03.Ph.D.2021.Sa.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sarah Salah Thabet Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Preparation, characterization and evaluation of novel nanoemulsions in photodynamic therapy / |
| Statement of responsibility, etc. | Sarah Salah Thabet Ali ; Supervised Maha Fadel Mohamed , Maha Nasr Sayed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير و وصف و تقييم مستحلب النانو الجديد في العلاج الضوئي الديناميكي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sarah Salah Thabet Ali , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 91 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences (NILES) - Department of Laser Applications in Medical and Biological |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The growing emergence of microbial resistance to antibiotics represents a worldwide challenge.Antimicrobial photodynamic inactivation (aPDI) has been introduced as an alternative technique, especially when combined with nanotechnology.Therefore, this study was designed to investigate the therapeutic merits of combined aPDI and nanoemulsion in infections caused by resistant bacterial strains. Cationic zinc (II) phthalocyanine nanoemulsions (ZnPc-NE) were prepared using isopropyl myristate (IPM) as oil phase, egg phosphatidylcholine (egg PC) as emulsifier, and N-cetyl-N,N,N-trimethyl ammonium bromide (CTAB).Nanoemulsions were characterized for particle size, polydispersity, zeta potential, viscosity, and skin deposition.The in-vitro aPDI was investigated on human resistant pathogens; gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and gram-negative multidrug-resistant strain of Escherichia coli (MDR E. coli), under different experimental conditions. In addition, in-vivo model of abrasion wound infected by MDR E. coli was induced in rats to investigate the therapeutic potential of the selected formulation. It was evident that the selected ZnPc formulation (20% IPM, 2% egg PC and 0.5% CTAB) displayed a particle size of 209.9 nm, zeta potential +73.1 mV, and 23.66% deposition of ZnPc in skin layers. Furthermore, the selected formulation combined with light achieved almost 100% eradication of the two bacterial strains, with superior bacterial load reduction and wound healing properties in-vivo, compared to either the nanoemulsion formulation or laser alone.This delineates that ZnPc nanoemulsion improved antimicrobial photodynamic therapy in inactivating resistant bacterial infections and introduced a promising therapeutic means of treating serious infections, and could be applied in diseases caused by other bacterial strains |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Egg phosphatidylcholine (egg PC) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Photodynamic therapy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Phthalocyanine nanoemulsions (ZnPc-NE) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Fadel Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Nasr Sayed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.24.03.Ph.D.2021.Sa.P | 01010110085114000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.24.03.Ph.D.2021.Sa.P | 01020110085114000 | 22.09.2023 | CD - Rom | 85114.CD |