Detection of IL-17A and IL-17F gene polymorphism in pityriasis versicolor and its relation to susceptibility to infection / (Record no. 83793)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03458cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032907.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220102s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.M.Sc.2021.Al.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Alia Mohamed Ahmed Hafez Ramadan |
| 245 10 - TITLE STATEMENT | |
| Title | Detection of IL-17A and IL-17F gene polymorphism in pityriasis versicolor and its relation to susceptibility to infection / |
| Statement of responsibility, etc. | Alia Mohamed Ahmed Hafez Ramadan ; Supervised Samar Mohamed Ragaie Eltahlawi , Rana Fathy Hilal , Olfat Gamil Shaker |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الكشف عن تعدد الأشكال الچينى لإنترليوكين ١٧أ و١٧ف فى التينيا الملونة وعلاقته بقابلية الإصابة بالمرض |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Alia Mohamed Ahmed Hafez Ramadan , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 132 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Pityriasis versicolor (PVC) is a superficial fungal infection caused by Malassezia species. A new entity of patients was described, characterized by recurrent disseminated pityriasis versicolor (RDPV) and was proven not to be infectious. Studies demonstrated the host genetic variation in immune response, particularly the role of IL-17 in antifungal immunity and skin inflammation.Sera of this entity of patients was examined for IL-17 gene polymorphism.Aim of work: To investigate IL-17A and IL-17F gene polymorphism in pityriasis versicolor patients in an attempt to reveal their role in pityriasis versicolor susceptibility. Methodology:A total of 100 patients with recurrent disseminated PVC with lesions measuring {u2265}10cm in at least one of their extensions, {u2265} 2 episodes of PVC in a year and a positive Wood{u2019}s light and/or direct mycological examination for Malassezia species, as well as100 gender and age matched controls were enrolled in this study. From each participant, 3 ml venous blood was withdrawn and put in EDTA tube for DNA extraction of IL-17A & IL-17F genes, using DNA extraction kit. Detection of single nucleotide polymorphism (SNP) occurred using real time PCR (polymerase chain reaction) with specific primers and probe. SNP was examined for both IL17A (rs2275913) and IL17F (rs763780), respectively, using the TaqMan technique. Result:A statistically significant difference was noted between patients and controls regarding the frequency of the mutant IL-17A (rs2275913) AA gene vs normal (wild) GG gene, as well as heterozygous IL-17F (rs763780) TC gene vs normal (wild) TT(p-value <0.001, respectively).In each case, the odds ratio was increased >1 indicating higher incidence of PVC in patients with mutation of IL-17A and IL-17F. A positive family history confers to the susceptibility to RDPV (p <0.001). No correlation was found between demographic and clinical data, and the IL-17 gene polymorphism. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IL-17A |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Interleukin-17 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pityriasis versicolor |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rana Fathy Hilal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samar Mohamed Ragaie Eltahlawi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.M.Sc.2021.Al.D | 01010110085138000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.M.Sc.2021.Al.D | 01020110085138000 | 22.09.2023 | CD - Rom | 85138.CD |