Designand synthesis of novel pyridopyrimidine derivatives of anticipated anti-cancer activity / (Record no. 83904)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03354cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032910.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220109s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2021.Kh.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Kholoud Fouad Aljamal |
| 245 10 - TITLE STATEMENT | |
| Title | Designand synthesis of novel pyridopyrimidine derivatives of anticipated anti-cancer activity / |
| Statement of responsibility, etc. | Kholoud Fouad Aljamal ; Supervised Amal Abdelhaleem Eissa , Heba Abdelrasheed Allam , Hany Said Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد مشتقات البيريدوبيريميدين الجديدة المتوقع لها فعالية كمضادات للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Kholoud Fouad Aljamal , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 145 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. Cancer is the second cause of mortality after cardiac diseases in the world. It is continuing to act as a major problem of health in both developing and developed countries. Accordingly, the search for new anticancer agents is extremely desirable to improve survival rates and minimize toxicities and drug resistance.Many researchers reported the importance of pyrido[2,3-d]pyrimidine as an interesting bioactive scaffold implicated in the development of anticancer agents. Also, literature survey highlighted the apoptotic activity of certain pyrido[2,3-d]pyrimidines leading to their anticancer effect. Accordingly, this research focused on the synthesis of novel pyrido[2,3-d]pyrimidines hoping to obtain promising anticancer agents with fewer side effects.The present investigation deals with the synthesis of bicyclic derivatives, namely: (4-substituted phenyl)pyrido[2,3-d] pyrimidin-4-amine IVa-h, 7-(4-methoxyphenyl)-4-(phenylamino)5-(4-substituted phenyl)pyrido[2,3-d] pyrimidin-2(1H)-thione Va-d, 1-(7-(4-methoxyphenyl)-3-phenyl-5-(4-substituted phenyl)-2-thioxo-2,3-dihydro pyrido[2,3-d]pyrimidin-4-yl)-3-phenyl thiourea VIa-d, 5-(4-(methylthio) phenyl)-7-(4-(un)substitute dphenyl)-2-thioxo-2,3-dihydropyrido[2,3-d] pyrimidin-4(1H)-one VIIa-d, 2-hydrazinyl-5-(4-(methylthio) phenyl)-7-(4-(un)substituted phenyl)pyrido [2,3-d]pyrimidin-4(3H)-one VIIIa,b, in addition to tricyclic derivatives: 3-amino-6-(4-(methylthio)phenyl)-8-(4-(un)substituted phenyl)-pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one IXa,b ,6-(4-(methyl thio)phenyl)- vii 8-(4-(un)substituted phenyl)-3-thioxo-2,3-dihydropyrido[2,3-d][1,2,4] triazolo[4,3-a]pyrimidin-5(1H)-one Xa,b. Compounds IVa-h, Va-d, VIa-d, VIIa-d and VIIIa,b were evaluated for their anticancer activity as EGFR inhibitors, using Gefitinib as a reference compound |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anti-cancer activity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyridopyrimidine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyrimidines |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amal Abdelhaleem Eissa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hany Said Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Abdelrasheed Allam , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2021.Kh.D | 01010110085226000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2021.Kh.D | 01020110085226000 | 22.09.2023 | CD - Rom | 85226.CD |