Diagnostic implication of urinary 8-hydroxy-2-eoxyguanosine (8-OHdG) as a novel biomarker for early prediction of diabetic kidney disease in adolescents with type 1 diabetes mellitus / (Record no. 84104)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03908cam a2200361 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032916.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220205s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.28.Ph.D.2021.Ba.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Basant Ahmed Abdelalim Ahmed |
| 245 10 - TITLE STATEMENT | |
| Title | Diagnostic implication of urinary 8-hydroxy-2-eoxyguanosine (8-OHdG) as a novel biomarker for early prediction of diabetic kidney disease in adolescents with type 1 diabetes mellitus / |
| Statement of responsibility, etc. | Basant Ahmed Abdelalim Ahmed ; Supervised Mona Mamdouh Abdelghafoor Hassan , Rasha Essam Eldin Galal , Laila Ahmed Rashed Ismail |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدلالة التشخيصية ل 8-هيدروكسى-2-دى أوكسى جوانوزين فى البول كمؤشر حيوى جديد للتنبؤ المبكر عن مرض الكلى السكري لدى البالغين المصابين بالسكرى من النوع الأول |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Basant Ahmed Abdelalim Ahmed , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 119 : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Diabetic microvascular complications (DMCs) involve nephropathy, retinopathy, and neuropathy. Diabetic kidney disease (DKD) is the most frequent and serious complication. It is the main cause of chronic kidney disease, which begins with normoalbuminuria and progresses to microalbuminuria, macroalbuminuria, and finally end stage kidney disease.The severity of DKD is assessed by the amount of albuminuria present, but it lacks the sensitivity and specificity needed to detect an early stage of DKD, so other biomarkers are needed. One of these biomarkers is urinary 8-Hydroxy-2-Deoxyguanosine (8-OHdG). Objectives:The aim of this study is to assess the sensitivity and specificity of urinary 8-OHdG as a novel biomarker for early detection of DKD in adolescents with type 1 diabetes mellitus (T1DM). Methods:The study included 91 participants; 64 adolescents with T1DM following at the DEMPU at Children's Hospital of Cairo University, and 27 healthy adolescents who were recruited as a control group from subjects accompanying their parents visiting sick siblings and relatives in Children's Hospital of Cairo University.T1DM patients were classified according to their urinary albumin/creatinine ratio (UACR) resultsinto 3 groups: group A (normoalbuminuria), group B (persistent microalbuminuria), and group C (recurrent microalbuminuria). A questionnaire was taken from T1DM patients; including: chronological age, gender, age at onset of T1DM, insulin dose, types, and regimen, use of angiotensin converting enzyme inhibitors (ACEIs), history suggestive of other diabetic complications, and history of other diseases (such as cardiovascular, renal, and urinary tract, hepatic, respiratory, neurodegenerative, and psychiatric diseases). Blood pressure and anthropometric measurements were performed for every participant. Laboratory tests were requested within 3 months of T1DM patient recruitment and included: glycosylated haemoglobin (HbA1c),full lipid profile (serum total cholesterol, serum triglycerides, serum low density lipoprotein-cholesterol, and serum high density lipoprotein-cholesterol), kidney function tests (serum creatinine and urea), and UACR |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Diabetic kidney disease |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetic kidney disease |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetic microvascular complications |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Type 1 diabetes mellitus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed Ismail , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Mamdouh Abdelghafoor Hassan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rasha Essam Eldin Galal , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.28.Ph.D.2021.Ba.D | 01010110085345000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.28.Ph.D.2021.Ba.D | 01020110085345000 | 22.09.2023 | CD - Rom | 85345.CD |