Assessment of potential anti-cancer stem cell activity of some natural compounds in breast cancer cells in vitro / (Record no. 84179)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02744cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032919.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220212s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.25.M.Sc.2021.He.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hebatallah Gamal Hafez Abdelhameed |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of potential anti-cancer stem cell activity of some natural compounds in breast cancer cells in vitro / |
| Statement of responsibility, etc. | Hebatallah Gamal Hafez Abdelhameed ; Supervised Rafat Milad Mohareb , Emad Fawzy Eskander |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقدير كفاءة بعض المركبات الطبيعية كمضادات للخلايا الجذعية السرطانية فى خلايا سرطان الثدى خارج جسم الكائن الحى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hebatallah Gamal Hafez Abdelhameed , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 125 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study aimed to appraise the activity of Jania rubens, Petrocladia capillacea, Corallina officinalis, Colpomenia sinuosa, Sargassum asperifolium and Sargassum dentifolium polysaccharides against breast cancer stem cells (BCSCs) in MDA-MB-231 and MCF-7 cell lines. These compounds were characterized to be sulfated polysaccharide-protein complexes. Cytotoxicity of the polysaccharides against MDA-MB-231, MCF-7 breast cancer cell lines and normal Vero E6 cells was assessed by MTT (3-(4,5-dimethylthiazol-2-yl)- 2,5- diphenyltetrazolium bromide) assay, and their impact on CD44+/CD24{u2212} and aldehyde dehydrogenase 1(ALDH1) positive BCSC population was determined by flow cytometry. Their effect on the gene expression of CSC markers, Wnt/Ý- catenin and Notch signaling pathways was evaluated by quantitative real-time PCR. All tested polysaccharides inhibited the growth of breast cancer cells with a more prominent action against MDA-MB-231 than MCF-7 cells at most time intervals along with their weaker cytotoxicity against Vero E6 cells, and reduced BCSC subpopulation. P. capillacea polysaccharides down-regulated the expression levels of OCT4, SOX2 and ALDH1A3 genes in MDA-MB-231 as well as in MCF-7 cells. C. officinalis polysaccharides exhibited similar effects on SOX2 and ALDH1A3 genes |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Anti-cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ntural compounds |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Potential anti-cancer stem |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Emad Fawzy Eskander , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rafat Milad Mohareb , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.25.M.Sc.2021.He.A | 01010110085400000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.25.M.Sc.2021.He.A | 01020110085400000 | 22.09.2023 | CD - Rom | 85400.CD |