MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03005nam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
220228s2021 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.12.21.M.Sc.2021.As.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Asmaa Ahmed Abdelkader |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Evaluation of the efficacy of nitazoxanide and amebazole in treatment of cryptosporidiosis in immunosuppressed mice / |
| Statement of responsibility, etc. |
Asmaa Ahmed Abdelkader ; Supervised Alyaa Ahmed Farid , Neveen Adel Madbouly , Ibrahim Rabae Shalash |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تقييم فاعلية النيتازوكسانيد والأميبازول فى علاج داء البوغيات الخبيثة فى الفئران المثبطة مناعيا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Asmaa Ahmed Abdelkader , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
70 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Cryptosporidium parvum (C. parvum) is an intestinal parasitic infection affecting both immunosuppressed and immunocompetent individuals. Considering the absence of effective treatment against cryptosporidiosis especially in immunodeficient patients, the present study was designed to assess the therapeutic efficacy of secnidazole (SEC) and its combination with nitazoxanide (NTZ) in comparison to single NTZ treatment in relation to the immune status on a murine model of C. parvum infection. The infected groups were administered NTZ, SEC or NTZ-SEC combination for 3 or 5 successive doses. At days 10 and 12, post infection (PI), the mice were sacrificed, and the efficacy of the applied drugs was evaluated by comparing the histopathological alterations in ileum and measuring the T helper (Th1): (Interferon Gamma; IFN-Þ), Th2: (Interleukin (IL)-4 and IL-10) and Th17: (IL-17) cytokine profiles in serum. The NTZ-SEC combination recorded the maximal reduction of C. parvum oocysts shedding, endogenous stages count and intestinal histopathology regardless to the immune status of the infected mice.The efficacy of NTZ-SEC combination was dependent on the period of administration as the 5 days based treatment protocol was more effective than 3 days based one in immunocompetence and immunosuppression as well.The present treatment schedule induced immunomodulatory effect of SEC that develops a protective immune response against C. parvum infection with reduced production of serum IL-17, IFN-Þ, IL-4 and IL-10. Application of NTZ-SEC combined therapy may be useful in treatment of C. parvum especially in case of immunosuppression |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Zoology |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Cryptosporidiosis |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Immunosuppressed |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Nitazoxanide |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Alyaa Ahmed Farid , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ibrahim Rabae Shalash , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Neveen Adel Madbouly , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
