MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03167cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
220305s2022 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.10.10.M.Sc.2022.Ba.V |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Basma Mohamed Hamed Ahmed |
| 245 14 - TITLE STATEMENT |
|---|
| Title |
The vaccines and their potential impact on antimicrobial resistance / |
| Statement of responsibility, etc. |
Basma Mohamed Hamed Ahmed ; Supervised Mona Ibrahem Elenbaawy , Eman Ragab Mohamed Mostafa |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
الفاكسينات و تأثيرها المحتمل على المقاومة للمضادات الحيوية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Basma Mohamed Hamed Ahmed , |
| Date of publication, distribution, etc. |
2022 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
99 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc. ) - Cairo University - Faculty of Veterinary Medicine - Department of Microbiology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Antimicrobial resistance (AMR) is now recognized as a major threat to global health. The present work aims to study the role of vaccine against AMR in broiler chickens using live avirulent multi-drug resistant E. coli vaccine also, investigate the additive effect of chitosan nanoparticles either as encapsulated or loaded form in another two live inactivated E. coli vaccine. Different samples from internal organs were collected from broiler from 10-38 day old. APEC was isolated by conventional culture methods and VITEK@ 2 COMPAT (bioMérieux, France) with prevalence ratio 67.5 %. Genes associated with virulence (iutA, fimC, and papC) were identified by PCR with the prevalence of 84.4%, 74%, and 54.8% of cases, respectively. Concerning antibiotic sensitivity test among the most resistant drugs, the highest rate of resistance was against Ampicillin (AM) (100%), Trimethoprim-Sulfamethoxazole (80%) Ampicillin-sulbactam (AMS) (78.5), Ceftazidime (CAZ) 75.5%, cefepime (CPM) 74 %. The vaccinal strain was selected to be avirulent and multidrug resistant. Four groups were designed for E. coli experimental vaccinal trial. The first was a negative control, the second was chitosan capsulated-antigen, the third was chitosan loaded-Ag, and the last group was immunized with live avirulent strain. Experiment vaccination revealed that antibody titer was measured by indirect ELISA and confirmed results by MAT shows that Only group 2 and 3 Significantly produced the highest response among groups. Also, the recovery of APEC from internal organs was the lowest in group 2,3 in comparison with group 4. It could be concluded that, administration of E. coli killed vaccine either loaded or encapsulated with chitosan nanoparticles promoted humeral immune response and antibody production as well as reduced APEC challenge loads. Also, E. coli vaccines based on chitosan are therefore a viable alternative to current vaccines for poultry |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Vaccines |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Antimicrobial Resistance |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Escherichia Coli |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Poultry |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Eman Ragab Mohamed Mostafa , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mona Ibrahem Elenbaawy , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
