MARC details
| 000 -LEADER |
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| fixed length control field |
04178nam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
220727s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.016.M.Sc.2021.No.H |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nour Mansour Abdelwahab |
| 245 10 - TITLE STATEMENT |
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| Title |
Histological and Immunohistochemical Study on the Therapeutic Effect of Calcipotriol/Betamethasone versus Exosomes and Black Seed Oil on Imiquimod-Induced Psoriasis-like Skin Injuries in Albino Rats / |
| Statement of responsibility, etc. |
Nour Mansour Abdelwahab ; Supervised Rahma Kamaleldin Abouelnour, Alshaymaa Gamal Aboulkhair , Rokia Mohamad Hassan |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة هستولوجية و هستوكيميائية مناعية عن التأثير العلاجي لعقار الكالسيبوتريول / بيتاميثازون مقارنة بالاكسوسومات و زيت الحبه السوداء علي اصابات الجلد الشبيهة بالصدفية المستحثة بالايميكيمود في الجرذان البيضاء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Nour Mansour Abdelwahab, |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
156 P . : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background: Psoriasis is a persistent, uncontrolled inflammatory disease characterized by red, scaly and irritated epidermal lesions. It not only deteriorates health but also has an impact on social life. Aim of work: The present study was designed to compare the therapeutic effect of calcipotriol/betamethasone versus exosomes and black seed oil on imiquimod-induced psoriasis-like skin injuries in male albino rats monitored by biochemical, histological and morphometric methods. Materials and Methods: Forty-five, 12 weeks-old male albino rats of an average body weight of 180-200 grams were used in this experiment. The back of all rats was shaved before the start of experiment. They were divided into 5 main groups: Group (I) Control (n= 15 rats): was divided into 5 subgroups received vaseline cream topically equivalent to the other groups. Group (II) Untreated (n=12 rats): was divided into 2 subgroups: (IIA) Psoriasis induced (n= 6 rats): aldara cream was topically applied once daily for 10 days and (IIB) Recovery (n= 6 rats): aldara cream was topically applied once daily for 10 days and left without treatment for next 10 days. Group (III) Calcipotriol/betamethasone treated (n= 6 rats): as subgroup IIA, then calcipoheal-cort was topically applied twice daily for next 10 days. Group (IV) Exosomes treated (n= 6 rats): as subgroup IIA, on the next day 200og exosomes was intravenously injected and left to be sacrificed at the end of the experiment. Group (V) Black seed oil treated (n= 6 rats): as subgroup IIA, then 0.3 ml of black seed oil topically applied once daily for next 10 days. All rats were sacrificed at the end of experiment (day 20) except subgroups IA & IIA in which rats were sacrificed at (day 10). Skin sections were stained with H&E, Masson~s trichrome and immunohistochemical staining for PCNA and Beclin1. Morphometric measurements and statistical analysis were done. Results: Topical application of IMQ induced psoriasis like inflammation in the form of erythema, scaling and thickening of the back skin of the rats. Treatment with calcipotriol/betamethasone, exosomes and black seed oil alleviate the psoriasis like injuries in the form of decreasing IL-23 level, skin inflammation, epidermal thickness, collagen deposition, keratinocytes proliferation and stimulating autophagy. Conclusion: Exosomes treated group showed the best results in ameliorating of psoriasis to an extent better than calcipotriol/betamethasone and black seed oil |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
histology |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
calcipotriol/betamethasone |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
exosomes |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
psoriasis |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Alshaymaa Gamal Aboulkhair , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rahma Kamaleldin Abouelnour , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rokia Mohamad Hassan , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Amira |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Enas |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
