The prevalence of the RUNX1 gene alterations in de novo acute myeloid leukemia using fluorescence in situ hybridization / (Record no. 84764)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03568nam a2200361 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032936.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220831s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2021.Na.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nada Sultan Mohamed Elsayed |
| 245 10 - TITLE STATEMENT | |
| Title | The prevalence of the RUNX1 gene alterations in de novo acute myeloid leukemia using fluorescence in situ hybridization / |
| Statement of responsibility, etc. | Nada Sultan Mohamed Elsayed ; Supervised Hoda Mohamed Abdelghany , Mona Shafik Elashry , Ahmed Magdy Rabea |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | FISH في المرضى الجدد لسرطان الدم النخاعي الحاد باستخدام تكنولوجيا التهجين في موقع مفلور RUNX1مدى انتشار التغير في جين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nada Sultan Mohamed Elsayed , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 224 P . : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and chemical pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by uncontrolled proliferation of hematopoietic progenitor cells with arrest of maturation and disruption of normal hematopoiesis. RUNX1 (Runt-related transcription factor 1) is a master regulator of definitive hematopoiesis where it regulates the differentiation of myeloid, megakaryocytic and lymphocytic lineage progenitors. RUNX1 is commonly disrupted by chromosomal translocations in hematological malignancies generating oncogenic fusion proteins or truncating RUNX1 that interfere with wild-type RUNX1. Genetic aberrations resulting in rearrangement of RUNX1, including generation of RUNX1 fusion genes, have been shown to be critical events in both myeloid and lymphoblastic acute leukemias. Aim of the work: is to detect the prevalence of RUNX1 gene alterations and its impact on clinical outcome in newly diagnosed AML patients. Various prognostic markers and other clinical and laboratory findings were studied in relation to RUNX1 gene alterations expressionPatients and methods: The current study was conducted on 77 newly diagnosed AML cases. Detection of RUNX1 alterations was done by florescence in-situ hybridization (FISH) technique. Results: The study revealed that RUNX1 abnormalities were detected by FISH in 41.6% of the studied patients including 20.8% were positive for RUNX1 translocations, 22.1% were positive for RUNX1 amplification and 5.2% were positive for RUNX1 deletion. RUNX1 deletion and DFS (Disease Free Survival) revealed a high statistically significant relation with p-value<0.001 with a mean of 3.033 months which indicates it carries the worst prognosis, while there was no statistically significant relation between RUNX1 abnormalities, RUNX1 translocations or RUNX1 amplification and DFS. Conclusion: inactivation of normal RUNX1 function is a potent key factor occurring early in the leukemogenic process and generally affects disease progression negatively. Therefore, targeting of RUNX1 has relevant significance as a new therapeutic strategy in AML |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | myeloid leukemia |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | AML |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | FISH |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | RUNX1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Magdy Rabea , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Mohamed Abdelghany , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Shafik Elashry , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2021.Na.P | 01010110085692000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2021.Na.P | 01020110085692000 | 22.09.2023 | CD - Rom | 85692.CD |