MARC details
| 000 -LEADER |
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| fixed length control field |
04578nam a2200361 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250223032938.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
220919s2022 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.11.30.Ph.D.2022.En.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Enas Samy Ibraheem Ali Elsisi |
| 245 10 - TITLE STATEMENT |
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| Title |
Effect of liraglutide on cognitive impairment in sepsis-survivors in adult male albino rats with type-2 diabetes / |
| Statement of responsibility, etc. |
Enas Samy Ibraheem Ali Elsisi ; Supervised Nahed Salaheldin , Laila Ahmed Rashed , sarah mahmood |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثير الليراجلوتايد علي تاخر الوظائف المعرفية في ذكور الفئران الناجون من تسمم الدم المصابون بداء السكري من النوع الثاني |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Enas Samy Ibraheem Ali Elsisi , |
| Date of publication, distribution, etc. |
2022 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
212 P . : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Diabetes mellitus and sepsis are major causes of cognitive decline. Liraglutide (LIRA) is a Glucagon like peptide-1 (GLP-1) agonist used by many diabetic patients with potential beneficial effects on the central nervous system. Objective: The purpose of the present study is to investigate the possible effect of liraglutide on cognitive decline in diabetes and sepsis. Methods: Male albino rats were divided into nine groups: Control (C), Drug control (Cd), Diabetes (D) (High fat diet for 2 weeks, Streptozotocin 40 mg/kg, (i.p.), once), Sepsis (S) (Cecal ligation and perforation (CLP)), Diabetic-Septic (DS) (Diabetes, CLP), Diabetes-treated rats (D-ttt) (Diabetes, LIRA (200 og/kg; i.p.; once daily, 4 weeks)), Sepsis treated rats (S-ttt) (Sepsis, LIRA), Diabetes-Sepsis treated group (DS-ttt) (Diabetes, CLP, LIRA), Diabetes and sepsis prophylaxis group (DS-pro) (Diabetes, CLP, LIRA (8 weeks). At the end of experimental period cognitive functions were assessed; blood glucose, insulin and HOMA-IR were measured. Oxidative stress, synaptic plasticity, and insulin signaling markers were assessed. Microglia, astrocytes were examined, in addition to H & E stain and electron microscopy examination of the hippocampus.Results: The results of the present study revealed that blood glucose levels, insulin and HOMA-IR in D and DS groups were all significantly increased (P<0.05) compared to C and Cd groups. LIRA treatment reversed all these changes in treatment groups. In cognitive tests (Ymaze test), the percentage of correct alternations was decreased significantly (P<0.05) in D and DS groups compared to C and Cd groups and all treatment groups showed a significant increase (P<0.05) in % of correct alternations compared to D and DS groups, while in Novel Object Recognition (NOR) test, the discrimination index (DI) showed a significant decrease (P<0.05) in D, S and DS groups compared to C and Cd groups. LIRA in D-ttt group caused a significant increase (P<0.05) in DI compared to D, S and DS group. In the hippocampus, oxidative stress markers (Tumor necrosis factor (TNF)- Ü and Malondialdehyde (MDA)) increased, while markers for synaptic function (Cyclic-AMP Response Element Binding Protein (CREB) and synaptophysin) decreased significantly (P<0.05), in D, S, and DS groups compared to C and Cd groups. Hippocampal insulin signaling markers, phosphorylatedserine/ threonine-specific protein kinase (p-Akt) decreased, while phosphorylated Mammalian target of rapamycin (p-mTOR) increased significantly (P<0.05) in D, S, and DS groups compared to C and Cd groups. Hippocampal Ionized calcium-binding adapter molecule-1(Iba1) and glial fibrillary acidic protein (GFAP), the count of Iba-1 positive microglia and GFAPpositive astrocytes were increased significantly (P<0.05) in D, S, DS groups compared to C and Cd groups. LIRA treatment reversed all these abnormalities. On H & E staining and electron microscopy examination of the hippocampus, many degenerative changes in all hippocampal regions were noted in D, S, and DS groups. LIRA in all treatment groups improved all these changes |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
type-2 diabetes |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
cognition |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Diabetes |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Sepsis |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Laila Ahmed Rashed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nahed Salaheldin , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
sarah mahmood , |
| Relator term |
|
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Amira |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
