MARC details
| 000 -LEADER |
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| fixed length control field |
04076nam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
220925s2022 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.19.04.Ph.D.2022.Mu.A. |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Mustafa Ahmed Mohamed Hussein |
| 245 10 - TITLE STATEMENT |
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| Title |
Association of PD-L1 Expression with Neoadjuvant Chemotherapy Response in Different Molecular Subtypes of Invasive Breast Carcinoma / |
| Statement of responsibility, etc. |
Mustafa Ahmed Mohamed Hussein , Supervised Mohamed Akram Nouh , Hoda Abdel-Raouf Ismail , Mona Ali Abd El-Fattah Saqr |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
بي دي ال ا في مختلف الأنواع الجزيئية لسرطان الثدي الغزوي و إرتباطه بتأثير العلاج الكيماوي قبل الجراحي في الورم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mustafa Ahmed Mohamed Hussein , |
| Date of publication, distribution, etc. |
2022 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
165 P. : |
| Other physical details |
Facsmilies , Charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis ( Ph.D.) - Cairo University - Faculty of National Cancer Institute - Department of Pathology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Although breast carcinoma had many targeted biomarkers for its treatment, it is a heterogenous disease with different outcomes and needs new markers especially for the triple negative group when estrogen, progesterone receptors and Her2/neu are negative. Programmed death-ligand 1 (PD-L1) is a new target with unclear role. The aim of this study was to examine the prevalence of PD-L1 in locally advanced invasive breast carcinoma and to elucidate its relation to tumor-infiltrating lymphocytes, breast carcinoma subtypes, established clinicopathological factors, pathological therapy response after neoadjuvant chemotherapy, disease-free survival and overall survival. Material and Methods: One hundred and five cases of locally advanced invasive breast carcinoma (stages IIB, IIIA, IIIB and IIIC) were evaluated for age, grade, tumor size, stage and node status (clinically before therapy and pathologically after therapy). The cases were retrieved immunohistochemically for estrogen receptor, progesterone receptor, Her2/neu and Ki-67. PD-L1 immunostaining was done and analyzed for all studied cases. Also, pretherapy tumor-infiltrating lymphocytes (TILs) density as well as TILs change after therapy were calculated and analyzed. Pathological therapy response was evaluated in all studied cases by different three pathological systems (Residual Cancer Burden, Miller-Payen grading system and Sataloff{u2019}s system). PD-L1 expression was correlated with pretherapy TILs density, TILs change, pathological therapy response, histopathological factors, breast cancer subtypes, 7-years DFS and overall survival. Results: PD-L1 was expressed in 32.4% of the studied cases. It was significantly associated with old age group, high grade tumors and high density (pretherapy) TILs. It was also expressed in a significant number of triple negative breast carcinoma (44.4%). PD-L1 negative breast cancer cases have better prognosis than those with PD-L1 positive breast cancer with statistically non-significant P value. There was no significant relation between PD-L1 and pathological therapy response, although, it revealed more expression in cases with complete therapy response. High change in TILs after therapy was strongly associated with complete and marked therapy response. Conclusion: Although the impact of PD-L1 on locally advanced breast cancer outcomes had not been clearly established, this result may provide evidence that PD-L1 is a bad prognostic and predictive marker. PD-L1 could be a new target for the treatment of patients with high grade breast carcinoma and TNBC group. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
chemotherapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Breast Carcinoma |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
breast conservative surgery |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Chemotherapy |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hoda Abdel-Raouf Ismail , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Akram Nouh , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mona Ali Abd El-Fattah Saqr , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Norhan |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
