MARC details
| 000 -LEADER |
|---|
| fixed length control field |
026020000a22003250004500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GICUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
061015s2005 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GICUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GICUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
Eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.Ph.D.2005.Gu.A. |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Guitar Samy Aly |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Association of n - acetyl transferase genetic polymorphisms with colorectal cancer / |
| Statement of responsibility, etc. |
Guitar Samy Aly ; supervised Ibtisam Farid , Tarek AlMahboub , Randa Mohamed Sabry Zaki |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تحديد الانماط الجينية للانزيم ان اسيتايل ترانسفيريز فى مرضى سرطان القولون باستخدام التفاعل المتسلسل بالبوليميريز |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Guitar Samy Aly , |
| Date of publication, distribution, etc. |
2005 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
143L : |
| Other physical details |
diagrs ; |
| Dimensions |
30cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Aromatic amines and heterocyclic amines are present in cigarette smokeHeterocyclic amines are also present in the diet as protein pyrolysis products formed when meat is cooked well doneThese carcinogens produce tumors at a number of sites but require host - mediated metabolic activation to mutate DNA and initiate carcinogenesisBoth N - Acetyltransferases , NAT1 and NAT2 , are important enzymes in the biotransformation of these carcinogensThey catalyze their N - acetylation (usually deactivation) and O - acetylation (usually activation) Genetic polymorphisms in NAT1 and / or NAT2 may modify risk associated with carcinogen exposuresFor cancers in which N - acetylation is a detoxification step such as aromatic amine - related urinary bladder cancer , NAT2 slow acetylator phenotype is expected to be at higher riskIn contrast , for cancers in which N - acetylation is negligible and O - acetylation is activation step such as for heterocyclic amine - related colon cancer , NAT2 rapid acetylator phenotype is expected to be at higher riskHuman epidemiological studies suggest that the NAT1 and NAT2 acetylation polymorphisms modifypredisposition to urinary bladder , colorectal , breast , head and neck , lung , and possibly prostate cancers |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Association of n - acetyltransferase |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Colorectal cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Genetic polymorphisms |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ibtisam Farid , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Randa Mohamed Sabry Zaki , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tarek AlMahboub , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Enas |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Mustafa |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
