Genetic mutation study among hepatocellular carcinoma patients : (Record no. 86294)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 029650000a22003490004500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223033023.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 061017s2006 ua a f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | Eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.08.Ph.D.2006.Sa.G. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sameera Ezzat AbouElKhair |
| 245 10 - TITLE STATEMENT | |
| Title | Genetic mutation study among hepatocellular carcinoma patients : |
| Remainder of title | Case control Study / |
| Statement of responsibility, etc. | Sameera Ezzat AbouElKhair ; Supervised Nargis Albert Labib , Laila Shehata Dorgham , Hussein Mostafa Khaled |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التحولات الجينيه لمرضى سرطان الكبد دراسة حالات وعينات ضابطة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sameera Ezzat AbouElKhair , |
| Date of publication, distribution, etc. | 2006 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 142P : |
| Other physical details | ill ; |
| Dimensions | 30cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Community Medicine |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwideThe aim of the present study was to assess the association of mutation of specific genes : cytochrome P450 1A1 (CYP1A1) , cytochrome P450 2D6 (CYP2D6) , microsomal epoxide hydrolase (EPHX) and paraoxonase (PON1) and environmental exposures on the risk of HCC in EgyptA case - control study was conducted on 459 subjects with confirmed HCC recruited from the National Cancer Institute , Cairo University , Egypt , and 634 controls recruited from orthopedic department , Cairo University Hospital , Egypt and from two villages in Menoufiya governoratePatients who agreed to participate signed a consent form , answered a questionnaire and gave a blood sample for hepatitis virus and genetic testingPON1 polymorphism was inversely related to HCC , OR was 07 (95in hundred CI : 05 - 11) EPHX1 Slow activity was significantly associated with HCC (OR= 15 , 95in hundred CI : 11 - 22) compared to high metabolizers after adjustment with age , sex , current HCV and current HBV infectionCYP1A1 mutation was not associated with HCC in the present study (OR= 20 , 95in hundred CI : 04 - 102) CYP2D6 extensive metabolizers was associated with HCC (OR= 18 , 95in hundred CI : 11 - 30) compared to poor metabolizersNo significant interaction between smoking or pesticides exposure and the studied genesAs expected , the strongest risk factors for HCC in this study were HCV RNA (OR = 11 - 13) and current HBV infection (OR = 6 - 9) This study therefore suggests that mutation in the studies genes are additive risk factors to current HCV and HBV infection |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Environment interaction |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gene |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hussein Mostafa Khaled , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Shehata Dorgham , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nargis Albert Labib , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Esam |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.08.Ph.D.2006.Sa.G. | 01010110045184000 | 22.09.2023 | Thesis | |
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.08.Ph.D.2006.Sa.G. | 01020110045184000 | 22.09.2023 | CD - Rom |