Prognostic role of neutrophil lymphocyteratio in advanced ovarian cancer / By Yomna Rashad Ahmed Kamal ; Under Supervision of Ahmed El-Saied El Bastawisy, Ahmed Magdy Rabea, Eman Zaghloul Kandeel.

By:

Yomna Rashad Ahmed Kamal

Contributor(s):

Eman Zaghloul Kandeel

Material type: Text

TextPublication details: 2022.Content type:

text

Media type:

Unmediated

Carrier type:

volume

Other title:

الذور التنبؤي للنسبة بين الخلايا المتعادلة والخلايا الليمفاوية في أورام المبيض المتقذمة

Subject(s):

Ovarian cancer

DDC classification:

618,9

Dissertation note: Thesis (M.Sc.)-Cairo University,2022. Summary: Objective: The purpose of this study was to determine the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and its dynamic change during chemotherapy in patients with advanced epithelial ovarian cancer undergoing chemotherapy. Methods: A retrospective analysis on patients who underwent for advanced-stage ovarian cancer at National Cancer institute between 2015 and 2018. Pretreatment NLR was evaluated before starting chemotherapy. Change in NLR was defined as the post treatment NLR value divided by the initial value. The correlation of NLR and its dynamic change with chemotherapy response score, response rate, and recurrence was analyzed. Results: A higher pretreatment NLR (>3.81) was associated with poor overall survival (OS), and progression-free survival (PFS). Through multivariate analysis, high pretreatment NLR was shown to be an independent parameter affecting OS and PFS. Changes in NLR during chemotherapy were better predictors of PFS than baseline NLR. Patients with increased NLR during chemotherapy showed significantly poor PFS and OS and this change was an independent predictor of PFS and OS.Conclusion: Pretreatment NLR and its dynamic change during chemotherapy may be important prognostic factors in patients who undergo neoadjuvant chemotherapy.

Tags from this library: No tags from this library for this title. Log in to add tags.

Average rating: 0.0 (0 votes)

Holdings
Item type	Current library	Home library	Call number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.19.04.M.Sc.2022.Yo.P (Browse shelf(Opens below))	Not for loan		01010110087176000

Browsing المكتبة المركزبة الجديدة - جامعة القاهرة shelves Close shelf browser (Hides shelf browser)

Previous	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	Next
Previous	Cai01.19.04.M.Sc.2022.Ol.D Differentiation syndrome in adult patients with acute promyelocytic leukemia at national cancer institute Cairo university (2015-2019) /	Cai01.19.04.M.Sc.2022.Ra.I Impact of neutrophil to lymphocyte ratio on response to neoadjuvant chemotherapy in solid tumors /	Cai01.19.04.M.Sc.2022.Sa.A Abdominal trachelectomy post subtotal hysterectomy (Supracervical Hysterectomy) single institutional study 10 years’ experience /	Cai01.19.04.M.Sc.2022.Yo.P Prognostic role of neutrophil lymphocyteratio in advanced ovarian cancer /	Cai01.19.04.M.Sc.2023.Ab.I Impact of Radiological Predictors on Surgical Management and Outcome of Carotid Body Tumor Resection /	Cai01.19.04.M.Sc.2023.Ah.T Treatment Outcomes in Metastatic Breast Cancer Females Older than Sixty Years /	Cai01.19.04.M.Sc.2023.Am.M Multi-centric experience in Lenalidomide Maintenance after Autologous Stem-Cell Transplantation in Multiple Myeloma /	Next

Thesis (M.Sc.)-Cairo University,2022.

Bibliography: p. 88-112.

Objective: The purpose of this study was to determine the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and its dynamic change during chemotherapy in patients with advanced epithelial ovarian cancer undergoing chemotherapy. Methods: A retrospective analysis on patients who underwent for advanced-stage ovarian cancer at National Cancer institute between 2015 and 2018. Pretreatment NLR was evaluated before starting chemotherapy. Change in NLR was defined as the post treatment NLR value divided by the initial value. The correlation of NLR and its dynamic change with chemotherapy response score, response rate, and recurrence was analyzed. Results: A higher pretreatment NLR (>3.81) was associated with poor overall survival (OS), and progression-free survival (PFS). Through multivariate analysis, high pretreatment NLR was shown to be an independent parameter affecting OS and PFS. Changes in NLR during chemotherapy were better predictors of PFS than baseline NLR. Patients with increased NLR during chemotherapy showed significantly poor PFS and OS and this change was an independent predictor of PFS and OS.Conclusion: Pretreatment NLR and its dynamic change during chemotherapy may be important prognostic factors in patients who undergo neoadjuvant chemotherapy.

There are no comments on this title.

to post a comment.