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Studying Studying the effect of gender on the response to the use of intravenous nalbuphine for post operative analgesia after laparoscopic cholecystectomy / by Tamer Fathy Tamer Younes ; Supervisors Prof. Dr.Amany Ezzat , Prof. Dr. Mohamed Mansour , Prof Dr. Ahmed Zaghloul.

By: Contributor(s): Material type: TextTextLanguage: English Summary language: English, Arabic Producer: 2023Description: 87 pages : illustrations ; 25 cm. + CDContent type:
  • text
Media type:
  • Unmediated
Carrier type:
  • volume
Other title:
  • / دراسة تأثير نوع الجنس على مدى فعالية عقار النالبيوفين المعطى وريديا لتسكين الألم بعد جراحة المرارة بالمنظار [Added title page title]
Subject(s): DDC classification:
  • 617.967
Available additional physical forms:
  • Issues also as CD.
Dissertation note: Thesis (Ph.D)-Cairo University, 2023. Summary: That’s why pain after laparoscopic cholecystectomy is considered multifactorial and independent on the gender of patients. Mu-, delta- and kappa-opioid receptors are widely expressed in the central nervous system where they mediate the strong analgesic and mood-altering actions of opioids, and modulate numerous endogenous functions(3). Nalbuphine is a mixed agonist/antagonist opioid that induce analgesia by acting predominantly at kappa opioid receptors, have recently been shown in single- dose studies to have greater analgesic efficacy in women than in men(4). Now, research has revealed that the same major types of opioid receptor interact differently depending on sex. The spinal cord of female laboratory animals was found to contain almost five times more kappa-mu heterodimer - a complex of mu- opioid and kappa-opioid receptor- than the spinal cord of male animals.
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2023.Ta.S (Browse shelf(Opens below)) Not for loan 01010110089259000
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Cai01.11.01.Ph.D.2023.Na.E Affect of sustained inflations on lung atelectasis during paediatric laparoscopic surgery as determined by lung ultrasound : A randomized controlled trial / Cai01.11.01.Ph.D.2023.Ne.P Prophylactic use of norepinephrine for prevention of intraoperative hypotension in infants undergoing kasai portoenterostomy operation for biliary atresia : double blinded randomized controlled trial / Cai01.11.01.Ph.D.2023.Om.C Comparison of the Hemodynamic Effects of Opioid-based Versus Lidocaine-based Induction of Anesthesia with Propofol in Elderly : A Randomized Controlled Study / Cai01.11.01.Ph.D.2023.Ta.S Studying Studying the effect of gender on the response to the use of intravenous nalbuphine for post operative analgesia after laparoscopic cholecystectomy / Cai01.11.01.Ph.D.2023.Ve.E Evaluation of the preoperative ultrasonographic evaluation of the transverse diameter of the right common femoral vein for predicting post-spinal hypotension in elderly patients : a prospective observational study / Cai01.11.016.M.Sc.2021.No.H Histological and Immunohistochemical Study on the Therapeutic Effect of Calcipotriol/Betamethasone versus Exosomes and Black Seed Oil on Imiquimod-Induced Psoriasis-like Skin Injuries in Albino Rats / Cai01.11.016.M.Sc.2021.No.H Histological and Immunohistochemical Study on the Therapeutic Effect of Calcipotriol/Betamethasone versus Exosomes and Black Seed Oil on Imiquimod-Induced Psoriasis-like Skin Injuries in Albino Rats /

Thesis (Ph.D)-Cairo University, 2023.

Bibliography: pages 69-85.

That’s why pain after laparoscopic cholecystectomy is considered multifactorial and independent on the gender of patients.
Mu-, delta- and kappa-opioid receptors are widely expressed in the central nervous system where they mediate the strong analgesic and mood-altering actions of opioids, and modulate numerous endogenous functions(3).
Nalbuphine is a mixed agonist/antagonist opioid that induce analgesia by acting predominantly at kappa opioid receptors, have recently been shown in single- dose studies to have greater analgesic efficacy in women than in men(4).
Now, research has revealed that the same major types of opioid receptor interact differently depending on sex. The spinal cord of female laboratory animals was found to contain almost five times more kappa-mu heterodimer - a complex of mu- opioid and kappa-opioid receptor- than the spinal cord of male animals.

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Text in English and abstract in Arabic & English.

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