Thesis (M.Sc.)-Cairo University, 2023.

Bibliography: pages 100-104.

Background: Assess the possibility of CT enterography (CTE) score system as a predictor in assessing active ulcerative colitis (UC) severity.
Methods: Sixty-six patients with active UC with CTE and colonoscopy were enrolled. Based on modified Mayo score, patients were divided into three groups: mild (n = 9), moderate (n = 25) and severe (n = 32). A cumulative CTE score was calculated in each patient and its correlation with modified Mayo score was analyzed. The optimal cutoff values of CTE score were determined by receiver operating characteristic (ROC) curves analysis.
Results:
Our CTE results reported related lymphadenopathy and perirectal stranding in 100% of cases, bowel wall thickening was found in 97%,mural hyperenhancement in 95.5% of cases, mural stratification in 90.9% of cases, mucosal bubbles in 53% of cases, loss of haustration in 36.4% of cases, mesenteric hyperemia in 69.7%, pseudopolyps in 39.4% and luminal narrowing in 10.8%, however, intestinal obstruction, air under diaphragm, perforation or leakage were never reported .Ascites was reported in one case .The optimal CTE score cut-off value for predicting mild and moderate UC was 7.5 with an area under the ROC curve of 0.996. The sensitivity and specificity were 92% and 100 %, respectively. The optimal CTE score cut-off value for predicting moderate and severe UC was 10.5 with an area under the ROC curve of 0.983 . The sensitivity and specificity were 90.6% and 100 %, respectively.
Conclusion: CT enterography (CTE) is a good tool for assessing disease activity in ulcerative colitis. Disease severity assessment by CTE score demonstrates strong positive correlation with severity established by modified Mayo score. So CTE score system in ulcerative colitis maybe a potential predictor for active UC severity assessment.

التهاب القولون التقرحي هو مرض التهاب الأمعاء المزمن.يتميز بالتهاب منتشر في الغشاء المخاطي للأمعاء.
أصبحت الأساليب الإشعاعية أدوات تشخيصية مهمة في حالات التهاب القولون التقرحي. يمكن استخدام التصوير غير التدخلي لتحديد شدة المرض والكشف عن المضاعفات المرتبطة بالمرض ومظاهر المرض خارج الأمعاء ويمكن استخدامه كبديل للمناظير ، عندما يكون لا حاجة لاخذ عينة من الأنسجة.
التصوير المقطعي المعوي هو أداة لتشخيص نشاط المرض في التهاب القولون التقرحي ، تقييم شدة المرض بدرجة التصوير المقطعي المعوي يرتبط ارتباطًا إيجابيًا قويًا بدرجة مايو المعدلة التي تم تحديدها. لذلك ، درجة التصوير المقطعي المعوي لاللتهاب القولون التقرحي مؤشراً محتملاً لتقييم شدة نشاط الالتهاب .

Issues also as CD.

Text in English and abstract in Arabic & English.