Thesis (M.Sc)-Cairo University, 2023.

Bibliography: pages 73-94.

Background: The ductus arteriosus is a central vascular shunt connecting the pulmonary artery to the aorta, allowing oxygenated blood from the placenta to bypass the uninflated fetal lungs and enter the systemic circulation. Rapid closure of the ductus arteriosus after birth is essential for vascular transition to the mature, divided pattern of arteriovenous circulation. Failure of ductus arteriosus closure termed patent ductus arteriosus (PDA).
Aim and objectives: to evaluate catheter closure versus surgical closure outcome of PDA in pediatric patients weighed between 2-6 kg in Cairo University.
Subjects and methods: This was a cross sectional analytic study conducted on 43 PDA Pediatric patients weighed between 2-6 kg in cardiology department specialized pediatric hospitals of Cairo University over 10 years since (2012-2023).
Results: There were two groups for PDA closure in our study, surgical group and catheterization group. Surgical group (n=23) and catheterization group (n=20), the weight range of the surgical group was (2.5-6) kg and catheterization group was (4.5-6) kg. There was a statistically significant difference between the two groups regarding age at intervention (days) with median and (IQR) in surgical group of 123 (96-198) and in catheterization group of 255 (188-308) with P value <0.001. There was a statistically significant difference between the two groups regarding weight (Kg) and height (cm) at procedure with median and IQR as weight in surgical group is 4.5 (3.2-5) and in catheterization group is 5.9 (5-6) with P value <0.001 and height in surgical group 59 (57-61) and in catheterization group is 64 (60-68) with P value equal 0.002. There was a statistically significant difference between the two groups regarding to hospital length of stay (days) as P value is <0.001.
Conclusion: Our study concluded that in Pediatric patients weighed between 2-6 kg surgical repair groups included lower weights than catheterization group and both closing methods for PDA resulted in complete technical success of procedure. Thus it is safe to use the catheterization technique for PDA patients weighed (4.5-6) kg, while we can restrict surgical referral for patients who weighed less than (4.5) kg. No deaths occurred in catheterization group indicating higher survival than surgical repair group.

القناة الشريانية هي تحويلة وعائية مركزية تربط الشريان الرئوي بالشريان الأبهر، مما يسمح للدم المؤكسج من المشيمة بتجاوز رئتي الجنين غير المنتفختين ودخول الدورة الدموية الجهازية. يعد الإغلاق السريع للقناة الشريانية بعد الولادة أمرًا ضروريًا للانتقال إلى نمط الدورة الدموية الشريانية-الوريدية المقسمة. فشل إغلاق القناة الشريانية يسمى القناة الشريانية السالكة.
القناة الشريانية السالكة هي واحدة من أكثر عيوب القلب الخلقية شيوعًا. تعرّف القناة الشريانية السالكة على أنها فشل القناة الشريانية في الإغلاق في غضون 72 ساعة بعد الولادة، وقد تؤدي إلى معدلات اعتلال ووفيات للأطفال تصل إلى 30٪. تشمل المضاعفات المحتملة للقناة الشريانية بعد الولادة القصور القلبي، واضطراب الوظائف الكلوية، والتهاب الأمعاء والقولون الناخر، والنزيف داخل البطيني، وتغيير التغذية والنمو بعد الولادة. بالإضافة إلى ذلك، تعد القناة الشريانية السالكة أحد عوامل الخطر للإصابة مرض الرئة المزمن.

Issues also as CD.

Text in English and abstract in Arabic & English.