Role of platelet glycoprotein ia allele polymorphism and platelet collagen receptor expression in acute coronary syndrome / Mariam Fayek Gobrial Youssef ; supervised Magda Ramzy Habib , Mervat Mohammed Wagih Mattar , Sahar KamalElDin

Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Internal Medicine

Platelet adhesion and aggregation have been found to have a major role in acute coronary syndromesLarge clinical trials have confirmed the benefit of antiplatelet therapy in the prevention and reduction of cardiac events associated with acute coronary syndromesInhibition of platelet aggregation by blocking the glycoprotien IIb / IIIa receptor on the platelet surface decreases the risk of thrombotic corornary occlusions in patients undergoing coronary angioplastyPlatelet glycoprotien IIIa polymorphism PI AI / A2 is an important inherited risk factor for coronary thrombosis and stent thrombosisPLA2 may be linked to another , as yet unidentified risk factorTwo linked and silent platelet polymorphisms in their glycoprotien Ia gene have been shown to be associated with an effect on platelet collagen receptor densityA four fold variation of the platelet receptor density of the collagen receptor glycoprotien Ia / IIa was found correlating with platelet function to adhere to collagen typeI and type IIIThe molecular basis of two silent polymorphisms at position 807C / T and 873G / A on the glycoprotien Ia gene was identified : individuals with low receptor densities are homozygous for the G allele , whereas individuals homozygous for the 807T / 873A allele have high receptor densities

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