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Expression of Vascular Endothelial Growth Factor and Its Receptors in Acute Leukemia / Manal Mohamed Mahmoud Makhlouf ; Supervised Nehad Mahmoud ElSheemy , Mona Salah ElDin Hamdy , Nahla Mohamed Leheta

By: Contributor(s): Language: Eng Publication details: Cairo : Manal Mohamed Mahmoud Makhlouf , 2006Description: 233P : ill ; 30cmOther title:
  • تواجد عامل نمو الغشاء المبطن للوعاء الدموى ومستقبلية فى حالات سرطان الدم الحاد [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology Summary: Vascular endothelial growth factor (VEGF) is one of the most potent and specific positive regulators involved in angiogenesisThe activity of VEGF is mediated by interaction with high affinity class III receptor tyrosine kinases (RTKs) , expressed on most endothelial cells , which are VEGFR - 1 (FLT - 1) , VEGFR - 2 (KDR) and VEGFR - 3 (FLT - 4) VEGF and its receptors may play a very important role not only in angiogenesis but also in leukemogenesisTheir expression on leukemic cells may elucidate its role as an autocrine promoter of malignant cell proliferation in acute leukemia whether myeloblastic or lymphoblastic and in other hematologic malignancies as they trigger proliferation , survival and migration of malignant hematopoietic cellsTheir expression may have clinical relevance and important role as risk and prognostic factors in acute leukemiaThey may be useful as predictive test for treatment outcome in acute leukemia patients
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Item type Current library Home library Call number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2006.Ma.E. (Browse shelf(Opens below)) Not for loan 01010110046066000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2006.Ma.E. (Browse shelf(Opens below)) Not for loan 01020110046066000

Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology

Vascular endothelial growth factor (VEGF) is one of the most potent and specific positive regulators involved in angiogenesisThe activity of VEGF is mediated by interaction with high affinity class III receptor tyrosine kinases (RTKs) , expressed on most endothelial cells , which are VEGFR - 1 (FLT - 1) , VEGFR - 2 (KDR) and VEGFR - 3 (FLT - 4) VEGF and its receptors may play a very important role not only in angiogenesis but also in leukemogenesisTheir expression on leukemic cells may elucidate its role as an autocrine promoter of malignant cell proliferation in acute leukemia whether myeloblastic or lymphoblastic and in other hematologic malignancies as they trigger proliferation , survival and migration of malignant hematopoietic cellsTheir expression may have clinical relevance and important role as risk and prognostic factors in acute leukemiaThey may be useful as predictive test for treatment outcome in acute leukemia patients

Issued also as CD

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