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Baclofen derivatives : Structural parameters vs. receptor sffinities and physicochemical properties as predicted from BCS characteristics / Islam Tariq Eddiasty ; Supervised Hilde Spahn - Langguth , Laila G. Mahran , Raimund Niess

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Islam Tariq Eddiasty , 2009Description: 99 Leaves : charts , facsimiles ; 30cmOnline resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: Baclofen a specific (gamma amino - butyric acid ) GABA B receptor agonist has successfully been used for decades for the treatment of spastic movement especially in instances of spinal cord injury spastic diplegia and multiple sclerosis . On the other hand the drug suffers from poor availabililty at the site of action the CNS despite its excellent intestinal absorption
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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Baclofen a specific (gamma amino - butyric acid ) GABA B receptor agonist has successfully been used for decades for the treatment of spastic movement especially in instances of spinal cord injury spastic diplegia and multiple sclerosis . On the other hand the drug suffers from poor availabililty at the site of action the CNS despite its excellent intestinal absorption

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