New diagnostic and therapeutic approach on abdominal pain in equines / Yasser Maher Sadek ; Supervised Fatma Mohamed Abd El Fatah Tayeb , Adel Abd El Baset Kubesy , Tarek Abd El Hamid Abdou

Thesis (M.Sc.) - Cairo University - Faculty Of Veterinary Medicine - Department Of Internal Medicine and Infectious Diseases

This study was carried out on160 apparently healthy foreign horse to study the incidence and clinical field findings and observations of equine colic beside the roles of equitation management and environment cited in causing of equine colic , as well as biochemical , pathophysiological , pathological and electron microscopic change findings associated with colic , in addition to the implicit roles of recent mycotoxins in diet of colicky horses to determine specific types and amountsHorses used for eventing , or in training had a significant higher incidence rate of colicAge revealed that the most susceptible age was (2 - 10) yearsMonthly and seasonal incidence of colic it was cleared that the apparitions of colic were strongly related to the hot weatherThe detection and determination of mycotoxine reveled that fumonisin exceeded the permissible limit which emphasized a risk factor for horses may considered in elevation the ID of colicData of leukon revealed significant leukocytosis with neutrophiliabiochemical profile in colicky horses cleared that some parameters were significantly decrease as total protein and sodiumOther was significantly increased as total bilirubin , lactat and creatinineGross cadaver examination showed enlargement congestion of liver , Kidneys , Lungs , Spleen and splenomegalyStomach showed signs of inflammation with severe congestionIntestine either small or large were suffered from enteritis with thin wall , obstruction either internally or externally lead to gangrene and even ruptureThe microscopic examination cleared that : Liver showed congestion of central vein , Kidney showed congestion of glomerular tuftHeart showed areas of hemorrhages , zenker's necrosisLung showed signs of passive hyperemia accompanied with areas of hemorrhagesSpleen showed hemorrhages and haemosidrosisBrain showed congestion of the blood vessels , nerve cells showed signs of necrosis , demylination , brain sand , focal gliosisIntestine either small or large showed desquamation of the epithelial lining of villi and crypt of Luber kuhen , Examination by transmission electron microscope revealed that , Liver showed margination of chromatin at peripheral of nucleusKidney showed signs of irreversible change in jury in proximal convoluted tubulesJejunum showedFeatures of apoptosis were detected represented by cells rounded up of the plastic exhibiting cytoplasmic blebing Fragmentation and chromatin condensationCecum showed necrosis of epithelial lining

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