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A pharmaceutical study on some modified release solid dosage forms of certain statins / Balqees Saeed Ahmed Mohamed Hazaa ; Supervised Ahmed Abdelbary Abdelrahman , Howida Kamal Ibrahim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Balqees Saeed Ahmed Mohamed Hazaa , 2011Description: 188 P. : charts ; 25cmOther title:
  • دراسة صيدلية على بعض الأشكال الصيدلية الصلبة محورة الإنطلاق لستاتينات معينة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Simvastatin is a potent inhibitor of 3- hydroxy - 3 - methy1 - glutary1 - coenzyme A ( HMG - CoA ) reductase and a cholesterol - lowering widely uaed to treat hypercholesterolemia . However, it gave poorly oral bioavailability ( < 5% ) due to its water - insolubility and extensive first pass metabolism by the CYP 450 isoform 3A4, and to a lesser degree, by CYP3A5, in the intestinal wall and liver
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2011.Ba.P (Browse shelf(Opens below)) Not for loan 01010110055816000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2011.Ba.P (Browse shelf(Opens below)) 55816.CD Not for loan 01020110055816000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Simvastatin is a potent inhibitor of 3- hydroxy - 3 - methy1 - glutary1 - coenzyme A ( HMG - CoA ) reductase and a cholesterol - lowering widely uaed to treat hypercholesterolemia . However, it gave poorly oral bioavailability ( < 5% ) due to its water - insolubility and extensive first pass metabolism by the CYP 450 isoform 3A4, and to a lesser degree, by CYP3A5, in the intestinal wall and liver

Issued also as CD

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