Deletion polymorphism of the angiotensin 1 converting enzyme gene and coronary artery ectasia / Nasser AbdAllah Ahmed Salem ; Supervised Hassan Khaled , Amr ElSayed ElHadidy , Ashraf Mohy ElDeen

Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Critical Care Medicine

CAE is not distinguishable from obstructive CAD in severity of angina , clinical presentation , ECG , mortality or outcome of coronary artery surgery CAE is not a benign entity since 735 of patients presented with a previous history of MI and 56 of them had angina The majority of patients were males , in the sixth decade with associated obstructive CAD with underlying smoking , obesity , hyperlipidemia and positive family history of CAD They had no relation to hypertension , diabetes mellitus or hyperuricemia The incidence of CAE in our series was 17 and there is some evidence to suggest that the incidence of ectasia is increasing RCA , LAD and CX were the most commonly involved vessels and most of the patients had single vessel diseaseThe DD genotype is the most common ACE gene polymorphism in CAE On the basis of our data , ACE DD genotype seems to be a potent risk factor for the development of CAE Understanding of the entity of CAE need to improve and warrants a detailed study on the available managementThe possible involvement of the renin - angiotensin system in the genesis of CAE raise the question of whether drugs that modulate activity of ACE and / or component of this system may reduce the risk for CAE

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